BEH Research interests (T6)

Key words

Research Themes

Our objectives will be to consider the molecular, cellular, metabolic and physiological mechanisms developed by organ-isms and / or humans to manage the environmental constraints and to understand correlation between environmental stress and plasticity of organisms. Different research programs support these researches, two of which could help for the development of new research institute around Aix-Marseille University, AMIDEX CREER closely related to “Reproduction & Environment” and AMIDEX PASSIV-ITER related to new energy technologies.

Our mains goals are :
• To understand and characterize the impacts taking into account biotic and abiotic factors,
• To describe and explain the observed effects by complementary approaches, ranging from molecular and cellular biology to physiological and behavioral analyses
• To conduct analyses in laboratory, experiments in mesocosms and realistic experiments in field.

At the ecosystem level, the persistence / presence of a species in a given environment depends on its sensitivity, vulnerability and adaptability. This persistence depends on physiological tolerance and genetic heritage of the species. The de-fense mechanisms generate a metabolic cost modifying the distribution of energetic reserves. Then, the reserves are allocated to the maintenance of homeostasis and not to the survival of the organism, leading to significant metabolic and physiological disorders.

In terms of human health, exposed and affected populations develop numerous pathologies including cancers, reproduc-tive disorders, metabolic disorders, accelerated tissue aging processes. The multifactorial aspect of pathologies, coupled with delayed effects, makes the relationship between environmental exposures and human health difficult to elucidate.
More specifically, we will study the impact of agricultural practices on non-target organisms to improve knowledge on species susceptibility, physiological functions and metabolic pathways (reproduction, development, immunity). Both, behavioral and population responses (life history traits, evolution of biodiversity) and interspecific interactions (competition between species) will be investigated.
Moreover, genotoxic stresses, including ecogenotoxic responses, induced by iatrogenic, particulate and/or chemical expo-sures, and the mechanism of action, direct or mediated by inflammatory or oxidative responses, will be investigated in germ and somatic cells and/or tissues. We will focus on the development of new biomarkers, including biomarkers of mutagenesis, related or not to reproductive, developmental, and immunity disorders.
We will assess the impacts of oxidative stress and inflammation on health. The study of biological or molecular processes (ex : dioxin receptor, type 2 diabetes and PCBs or PAHs, extrinsic cell aging) involved in the effects of pollutants allows the identification of molecular targets against which new molecules synthetized by organic chemistry, (Eg : antioxidant flavonols), biotechnologies (eg PROTAC approach), or extracted from species constitutive of biodiversity (eg toxins from cnidarians, photo-protectors present in coral mucus) will be documented. The vectorization of these active molecules (eg « Solid Lipidic Nanoparticles ») and ecorestorative approaches (eg nano-composites) will also be carried out, underlining the integrative nature of our approach.
We will continue to develop experimental models to document the genotoxic effects of chemical, particulate or physical agents on the tissues involved in reproductive function in humans, whether they are germinal cells or not, but also in terrestrial and aquatic model organisms (earthworm, freshwater hydra, gammarus...)

Hydra circumcinta (Cnidaria)

Because of our multidisciplinarity, we will be able to cover large methodological field such QSAR, biostatistics, biochemical, biophysical (cellular bioenergetics) or molecular biology (transcriptomics and genomics) techniques allowing us to document epigenetic effects (methylation, DNA, miRNA, etc.), and genotoxic effects including primary DNA lesions (comet assay), genetic mutations (Ames test, Pig-A test), and chromosome damage (micronucleus assay in combination with centromere labelling).
Health investigations on both biotope and population will help us to describe and to understand molecular and physiological processes impacted by anthropogenic pressure in a specific context. These integrative studies should lead to relevant tools to guide the conditions of a sustainable development taking into consideration quality and health of the environ-ment.
Our work aims to federate project in closed relationship with the transversal theme “Anthropocene and Health » et “Agricultural practices and Biodiversity Interactions over time ».


Brazil : Universidade Estadual de Campinas (Limeira)

Tunisia : University of Sfax

Maroco : University Ibnou Zohr-Agadir

France : University of Bordeaux I and II, University of Lyon I, University of Metz, University of Nîmes, INERIS, IRSN, CEA Cadarache, Eco-Med Society (Marseille), Agence de l’Eau (French Water agency, Marseille)


ANR DOMTOM (Porteur  : V. Hornebecq, membres  : Bergé-Lefranc D., Chaspoul F.)



Bergé-Lefranc D., Hornebecq V., Zelenak V., Benova E., Almasi M., Huntosova V. 2020. Adsorption properties, the pH-sensitive release of 5-fluorouracil and cytotoxicity studies of mesoporous silica drug delivery matrix. Applied Surface Science, 504 : 144028.

Colpaert R, Villard P.H., De Jong L., Mambert M., Benbrahim K., Abraldes J., Cerini C., Pique V., Robin M., Moreau X. 2020. Multi-scale impact of chronic exposure to environmental concentrations of chlordecone in freshwater cnidarian, Hydra circumcincta. Environmental Science and Pollution Research (sous presse)

Desbiolles F., Moreau X., de Jong L., Malleret L., Grandet-Marchant Q., Wong-Wah-Chung P., Laffont-Schwob I. 2020. Advances and limits of two model species for ecotoxicological assessment of carbamazepine, two by-products and their mixture at environmental level in freshwater. Water Research. 169:115267.
doi : 10.1016/j.watres.2019.115267. Epub 2019 Nov 6.


Bailly A.L., Correard F., Popov A., Tselikov G., Chaspoul F., Appay R., Al-Kattan A., Kabashin A.V., Braguer D., Esteve M.A. 2019. In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles. Scientific Report, 9(1):12890. doi : 10.1038/s41598-019-48748-3

Dron J., Revenko G., Chamaret P., Chaspoul F., Wafo E., Harmelin-Vivien M. 2019. Contaminant signatures and stable isotope values qualify European conger (Conger conger) as a pertinent bioindicator to identify marine contaminant sources and pathways. Ecological Indicators 107 : 105562. ⟨ doi : 10.1016/j.ecolind.2019.105562⟩

Gnansounou S.M., Iskandar S. , Abou L., Robin M., DI Giorgio C., Ahoussi E.D., Piccerelle P., Sonhounhloue D.K. 2019. GC-MS screening and evaluation of the anti-inflammatory and antioxidant activities of ethanolic leaves and stem barks extracts from Dialium guineense Willd, Parkia biglobosa (Jacq.) R. Br. ex Benth. and Tamarindus indica L. Journal of Pharmacognosy and Phytochemistry, 8(1) : 295-301.

Hamrouni R., Claeys-Bruno M., Molinet J., Masmoudi A., Roussons S., Dupuy N. 2019. Challenges of enzymes, conidia and 6-pentyl-alpha-pyrone production from solid-state-fermentation of agroindustrial wastes using experimental design and T. asperellum strains. Waste and Biomass Valorization, 1-12. doi:10.1007/s12649-019-00908-2

Jacquin L., Gandar A., Aguirre-Smith M., Perrault A., Le Hénaff M., De Jong L., Paris-Palacios S., Laffaille P., Jean S. 2019. High temperature aggravates the effects of pesticides in goldfish. Ecotoxicology and Environmental Safety, 172 : 255-264.

Manasfi T., De Méo M., Coulomb B., Di Giorgio C., Ravier S., Boudenne J.L. 2019. Development of transient mutagenic activity following the chlorination of the sunscreen UV filter dioxybenzone (benzophenone-8) in bromide-rich water. International Journal of Hygiene and Environmental Health, 222(4):663-669. doi : 10.1016/j.ijheh.2019.04.003.

Rigaud S., Garnier J.M., Moreau X., De Jong-Moreau L., Mayot N., Chaurand P., Radakovitch O. 2019. How to assess trace elements bioavailability for benthic organisms in lowly to moderately contaminated coastal sediments ? Marine Pollution Bulletin, 140 : 86-100.

Spitz C., Mathias F., Péchiné S., Doan T.H.D., Innocent J., Pellissier S., Di Giorgio C., Crozet M.D., Janoir C., Vanelle P. 2019 . 2,4-disubstituted 5-nitroimidazoles potent against Clostridium difficile. ChemMedChem, 14(5):561-569. doi : 10.1002/cmdc.201800784.

Uboldi C., Sanles Sobrido M., Bernard E., Tassistro V., Herlin-Boime N, Vrel D., Garcia-Argote S., Roche S., Magdinier F., Dinescu G., Malard V., Lebaron-Jacobs L., Rose J., Rousseau B., Delaporte P., Grisolia C., Orsiere T. 2019. In vitro analysis of the effects of ITER-Like tungsten nanoparticles : cytotoxicity and epigenotoxicity in BEAS-2B cells. Nanomaterials, MDPI, 9:1233.⟩. ⟨10.3390/nano9091233

Zeamari K., Gerbaud G., Grosse S., Fourmond V., Chaspoul F., Biaso F., Arnoux P., Sabaty M., Pignol D., Guigliarelli B., Burlat B. 2019. Tuning the redox properties of a [4Fe-4S] center to modulate the activity of Mo-bisPGD periplasmic nitrate reductase. Biochimica biophysica acta - Bioenergetics, 1860(5):402-413, doi : 10.1016/j.bbabio.2019.01.003


Amouroux M., Mieusset R., Desbriere R., Opinel P., Karsenty G., Paci M., Fernandes S., Courbiere B., Perrin J. 2018. Are men ready to use thermal male contraception ? Acceptability in two French populations : New fathers and new providers. PLoS ONE 13:e0195824, doi : 10.1371/journal.pone.0195824

Auffan M., Liu W., Brousset L., Scifo L., Pariat A., Sanles M., Chaurand P., Angeletti B., Thiéry A, Masion A., Rose J. 2018. Environmental exposure of a simulated pond ecosystem to a CuO nanoparticle-based wood stain throughout its life cycle. Environmental Science‎ Nano, 5:2579-2589, doi : 10.1039/c8en00712

Barral C., Castellano R., Tassistro V., Goubard A., Perrin J., Courbière B. 2018. Transmission of oocyte DNA damage to preimplantation embryos after in vivo mouse exposure to daunorubicin and cytarabine. Human Reproduction 33:135-

Belkair S.A., Mazzia C., Pasquet A., Capowiez Y. 2018. Temporal activity of spiders and earwigs during winter in apple trees under a Mediterranean climate. Biocontrol Science and Technology 28:823-836.

Belliardo C., Di Giorgio C., Chaspoul F., Gallice P., Berge-Lefranc D. 2018. Direct DNA interaction and genotoxic impact of three metals : Cadmium, nickel and aluminum. Journal of Chemical Thermodynamics, 125:271-277.

Blanchet M., Borselli D., Rodallec A., Peiretti F., Vidal N., Bolla J.M., Di Giorgio C., Morrison K.R., Wuest W.M., Brunel J.M. 2018. Claramines : A new class of broad-spectrum antimicrobial agents with bimodal activity. ChemMedChem, 13:1018-1027, doi : 10.1002/cmdc.201800073

Bricou A., Bendifallah S., Daix-Moreux M., Ouldamer L., Lavoué V., Benbara A., Huchon C., Canlorbe G., Raimond E., Coutant C., Graesslin O., Collinet P., Carcopino X., Touboul C., Daraï E., Carbillon L., Ballester M. 2018. A proposal for a classification for recurrent endometrial cancer : Analysis of a French multicenter database from the FRANCOGYN Study Group. International Journal of Gynecological Cancer, 28:1278-1284, doi : 10.1097/igc.0000000000001296

Brun A., Mor A.A., Bourrelly M., Dalivoust G., Gazazian G., Boufercha R., Lehucher-Michel M., Sari-Minodier I. 2018. Radiation protection for surgeons and anesthetists : practices and knowledge before and after training. Journal of Radiological Protection, 38:175-188, doi : 10.1088/1361-6498/aa9dbd

Brunel F., Lautard C., di Giorgio C., Garzino F, Raimundo J-M, Bolla JM, Camplo M. 2018. Antibacterial activities of mono-, di- and tri-substituted triphenylamine-based phosphonium ionic liquids. Bioorganic & Medicinal Chemistry Letters 28:926-929.

Blanchet M., Borselli D., Rodallec A., Peiretti .F, Vidal N., Bolla J.M., Di Giorgio C., Morrison K.R., Wuest W.M., Brunel J.M. 2018. Claramines : A new class of broad‐spectrum antimicrobial agents with bimodal activity. ChemMedChem, 13(10), 1018-1027.

Camus C., Vitale S., Loubatier C., Penaranda G., Khiri H, Plauzolles A., Carcopino X., Halfon P., Giordanengo V. 2018. Quantification of HPV16 E6/E7 mRNA spliced isoforms viral load as a novel diagnostic tool for improving cervical cancer screening. Journal of Clinical Medicine, 7(12):530, doi : 10.3390/jcm7120530

Carboue Q., Claeys-Bruno M., Bombarda I., Sergent M., Jolain J., Roussos S. 2018. Experimental design and solid state fermentation : A holistic approach to improve cultural medium for the production of fungal secondary metabolites. Chemometrics and Intelligent Laboratory Systems 176:101-107.

Carcopino X., Mancini J., Gondry J., Chevreau J., Lamblin G., Atallah A., Lavoue V., Caradec C., Baldauf JJ., Bryand A., Henno S., Agostini A., Douvier S., Jarniat A., Riethmuller D., Mendel A., Brun JL., Rakotomahenina H., Preaubert L. 2018. Risk Factors of Inadequate Colposcopy After Large Loop Excision of the Transformation Zone : A Prospective Cohort Study. Journal of Lower Genital Tract Disease 22:31-37.

Chaurand P., Liu W., Borschneck D., Levard C., Auffan M., Paul E., Collin B., Kieffer I., Lanone S., Rose J., Perrin J. 2018. Multi-scale X-ray computed tomography to detect and localize metal-based nanomaterials in lung tissues of in vivo exposed mice. Scientific Reports 8.

Claeys-Bruno M., Gomes C., Bruno C., Sergent M. 2018. Comparative study of mixture designs for complex phenomena. Chemometrics and Intelligent Laboratory Systems 178:65-72.

Couturier M.M., Ladeveze S., Sulzenbacher G., Ciano L., Fanuel M., Moreau C., Villares A., Cathala B., Chaspoul F., Frandsen K., Labourel A., Herpoël-Gimbert I., Gimbert Grisel S.S., Haon M., Lenfant N., Rogniaux H., Ropartz D., Davies G., Rosso M., Walton P., Henrissat B.B., Berrin J.G. 2018. Lytic xylan oxidases from wood-decay fungi unlock biomass degradation. Nature Chemical Biology, 14:306-310, doi : 10.1038/nchembio.2558

Da Costa L., Scheers E., Coluccia A., Rosetti A., Roche M., Di Giorgio C., Neyts J., Terme .T, Cirilli R., La Regina G., Silvestri R., Mirabelli C., Vanelle P. 2018. Structure-based drug design of potent pyrazole derivatives against rhinovirus replication. Journal of Medicinal Chemistry, 61:8402-8416, doi : 10.1021/acs.jmedchem.8b00931

Djamali M., Gondet S., Ashjari J., Aubert C., Brisset E., Longerey J., Marriner N., Mashkour M., Miller N..F, Naderi-Beni A., Pourkerman M., Rashidian E., Rigot J.B., Shidrang S., Thiéry A., Gandouin E. 2018 . Karstic spring wetlands of the Persepolis Basin, southwest Iran : unique sediment archives of Holocene environmental change and human impacts. Canadian Journal of Earth Sciences, 55:1158-1172. doi : 10.1139/cjes-2018-0065

Duclos G., Hili A., Resseguier N., Kelway C., Haddam M., Bourgoin A., Carcopino X., Zieleskiewicz L., Leone M. 2018. Clearsight (TM) use for haemodynamic monitoring during the third trimester of pregnancy - a validation study. International Journal of Obstetric Anesthesia, 36:85-95, doi : 10.1016/j.ijoa.2018.04.009

Esquerre-Lamare C., Walschaerts M., Debordeaux L.C., Moreau J., Bretelle F., Isus F., Karsenty G., Monteil L., Perrin J., Papaxanthos-Roche A., Bujan L. 2018. Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss : a multicenter case-control study. Basic and Clinical Andrology 28, 4. doi : 10.1186/s12610-018-0070-6

Garayev E., Di Giorgio C., Herbette G., Mabrouki F., Chiffolleau P., Roux D., Sallanon H., Ollivier E., Elias R., Baghdikian B. 2018. Bioassay-guided isolation and UHPLC-DAD-ESI-MS/MS quantification of potential anti-inflammatory phenolic compounds from flowers of Inula montana L. Journal of Ethnopharmacology 226:176-184.

Gay C, Cros A, Berbis J, Bretelle F, Perrin J., Courbiere B. 2018. Evaluation of « Energy Resonance by Cutaneous Stimulation » among women treated by in vitro fertilization. Journal of Alternative and Complementary Medicine 24:578-583.

Giraud A.S., Amar-Hoffet A., Boyer P., Courbiere B., Guillemain C. 2018. Between « pragmatic » interpretation and « disturbing » understanding : Embryonic cryopreservation for IVF patients. Gynécologie Obstétrique Fertilité & Sénologie 46:395-402.

Gomes C., Claeys-Bruno M., Sergent M. 2018. Space-filling designs for mixtures. Chemometrics and Intelligent Laboratory Systems 174:111-127.

Ianos O., Sari-Minodier I., Villes V., Lehucher-Michel M.P., Loundou A., Perrin J. 2018. Meta-analysis reveals the association between male occupational exposure to solvents and impairment of semen parameters. Journal of Occupational and Environmental Medicine, 60:E533-E542.

Iskandar S., Gnansounou S.M., Robin M., Lorquin J, Di Giorgio C., Piccerelle P. 2018. Antioxidant, anti-inflammatory and neuroprotective activities of a plant extract derived from traditional Chinese medicine : SuHeXiang Wan (AT000). Chemistry of Advanced Materials 3(2):36-59.

Jegaden M., Bouhnik A.D., Preau M., Bendiane M.K., Peretti-Watel P., Mancini J., Courbière B. 2018. Fertility status perception, fertility preservation and desire to have children in cancer survivors : French VICAN survey. Future Science Oa , 4(10):4FSO343. doi : 10.4155/fsoa-2018-0018

Jouni F., Sanchez-Hernandez J.C., Mazzia C., Jobin M., Capowiez Y., Rault M. 2018. Interspecific differences in biochemical and behavioral biomarkers in endogeic earthworms exposed to ethyl-parathion. Chemosphere, 202:85-93.

Loret E., Luis J., Nuccio C., Villard C., Mansuelle P., Lebrun R., Villard P.H. 2018. A low molecular weight protein from the sea anemone Anemonia viridis with an anti-angiogenic activity. Marine drugs, 16 : 134.

Malapert A., Reboul E., Tourbin M., Dangles O., Thiéry A., Ziarelli F., Tomao V. 2018. Characterization of hydroxytyrosol-β-cyclodextrin complexes in solution and in the solid states, a potential bioactive ingredient. LWT - Food Science and Technology, 102:317-323, doi:10.1016/j.lwt.2018.12.052

Marinho Reis A.P., Cave M., Sousa A.J., Wragg J., Rangel M., Oliveira A., Patinha C., Rocha F., Orsiere T., Noack Y. 2018. Lead and zinc concentrations in household dust and toenails of the residents (Estarreja, Portugal) : a source-pathway-fate model. Environmental Science : Processes & Impacts, 20:1210-1224, doi : 10.1039/c8em00211h

Martin-Chave A., Beral C., Mazzia C., Capowiez Y. 2018. Agroforestry impacts the seasonal and diurnal activity of dominant predatory arthropods in organic vegetable crops. Agroforestry Systems online :1-17 doi : 10.1007/s10457-018-0309-4

May P., Bremond P., Sauzet C., Piccerelle P., Grimaldi P., Champion S., Villard P.H. 2018. In vitro cocktail effects of PCB-DL (PCB118) and bulky PCB (PCB153) with BaP on adipogenesis and on expression of genes involved in the establishment of a pro-inflammatory state. International Journal of Molecular Sciences, 19 : 841.

Mazzia C., Munir K., Wellby M., Rault M., Capowiez Y., Gooneratne R. 2018. Nerve conduction velocity as a non-destructive biomarker in the earthworm Aporrectodea caliginosa exposed to insecticides. Environmental Science and Pollution Research 25:24362-24367.

Moiroux J., Boivin G., Brodeur J. 2018. Ovigeny index increases with temperature in an aphid parasitoid : Is early reproduction better when it is hot ? Journal of Insect Physiology 109:157-162, doi : 10.1016/j.jinsphys.2018.06.001

Moiroux J., Chesnais Q., Spicher F., Verrier E., Ameline A., Couty A. 2018. Plant virus infection influences bottom-up regulation of a plant-aphid-parasitoid system. Journal of Pest Science 91:361-372, doi : 10.1007/s10340-017-0911-7

Moiroux J., van Baaren J., Poyet M., Couty A., Eslin P., Prévost G., Seguin J., Le Roux V. 2018. Response of life-history traits to artificial and natural selection for virulence and nonvirulence in a Drosophila parastitoid, Asobara tabida. Insect Science 25:317-327, doi : 10.1111/1744-7917.12428

Nabokoff P., Tintori G., Bergé-Lefranc D., Redon S., Broggi J., Vanelle P. 2018. Base-free generation of super electron donors from air-stable precursors. Angwandte Chemie, doi : 10.1002/anie.20173079.

Plumejeaud S., Reis A.P., Tassistro V., Patinha C., Noack Y., Orsiere T. 2018. Potentially harmful elements in house dust from Estarreja, Portugal : characterization and genotoxicity of the bioaccessible fraction. Environmental Geochemistry and Health 40:127-144.

Préaubert L., Tassistro V., Auffan M, Sari-Minodier I., Rose J., Courbière B., Perrin J. 2018. Very low concentration of cerium dioxide nanoparticles induce DNA damage, but no loss of vitality, in human spermatozoa. Toxicology in Vitro 50:236-241.

Ratier A., Dron J., Revenko G., Austruy A., Dauphin C.E., Chaspoul F., Wafo E. 2018. Characterization of atmospheric emission sources in lichen from metal and organic contaminant patterns. Environmental Science and Pollution Research, 25:8364-8376, doi : 10.1007/s11356-017-1173-x

Redman C., Petry U., Leeson S., Niemenen P., Carcopino X., Bergeron C., Reich O. 2018. What gynaecologists need to master : Consensus on medical expertise outcome of pan-European postgraduate training in obstetrics and gynecology. European Journal of Obstetrics & Gynecology and Reproductive Biology 222:182

Sanchez-Hernandez J.C., Notario del Pino J., Capowiez Y., Mazzia C., Rault M. 2018. Soil enzyme dynamics in chlorpyrifos-treated soils under the influence of earthworms. Science of the Total Environment 612:1407-1416.

Soen S., Perrin J., Sari-Minodier I., Jouve E., Gnisci A., Courbiere B. 2018. Lower pregnancy rates after IVF in women working as occupational cleaners a preliminary pongitudinal study. Journal of Reproductive Medicine 63:33-38.

Suchail S., Le Navenant A., Capowiez Y., Thiéry A., Rault M. 2018. An exploratory study of energy reserves and biometry as potential tools for assessing the effects of pest management strategies on the earwig, Forficula auricularia L. Environmental Science and Pollution Research 25:22766-22774.

Sunyach C., Antonelli B., Tardieu S., Marcot M., Perrin J., Bretelle F. 2018. Environmental health in perinatal and early childhood : awareness, representation, knowledge and practice of southern France perinatal pealth professionals. International Journal of Environmental Research and Public Health 15(10). pii : E2259. doi : 10.3390/ijerph15102259.

Sunyach C., Didierjean H., Bretelle .F, Perrin J., Courbière B. 2018. Knowledge and attitudes of midwives regarding reprotoxic agents during pregnancy : snapshot of the Marseille area, southern France. Minerva ginecologica 71(3):256-259

Tintori G., Nabokoff P., Buhaibeh R., Bergé-Lefranc D., Redon S., Broggi J., Vanelle P. 2018. Base-free generation of organic electron donors from air-stable precursors. Angewandte Chemie International Edition, 57:3148-3153, doi : 10.1002/anie.201713079

Vincentelli C., Maraninchi M.M., Valero R., Béliard S., Maurice F., Emungania O., Berthet B., Lombard E., Dutour A., Gaborit B., Courbiere B. 2018. One-year impact of bariatric surgery on serum anti-Mullerian-hormone levels in severely obese women. Journal of Assisted Reproduction and Genetics, 35:1317-1324, doi : 10.1007/s10815-018-1196-3



Abram P., Boivin G., Moiroux J., Brodeur J. 2017. Behavioural effects of temperature on ectothermic animals : unifying thermal physiology and behavioural plasticity. Biological Reviews, 92:1859-1876, doi :10.1111/brv.12312

Ali S., Chaspoul F., Anderson L., Berge-Lefranc D., Achard V., Perrin J., Gallice P., Guichaouau. M. 2017. Mapping fifteen trace elements in human seminal plasma and sperm DNA. Biological Trace Element Research, 175 : 244-252.

Aubert C., Brisset E., Djamali M., Sharifi A., Ponel P., Gambin B., Azirani T.A., Guibal F., Lahijani H., Beni A.N., de Beaulieu J.L., Pourmand A., Andrieu-Ponel V., Thiéry A., Gandouin E. 2017. Late glacial and early Holocene hydroclimate variability in northwest Iran (Talesh Mountains) inferred from chironomid and pollen analysis. Journal of Paleolimnology, 58:151-167, doi : 10.1007/s10933-017-9969-8

Bonnefoy A., Plumejeaud S., Noack Y., Robin D., Doumenq P., Chaspoul F., Tassistro V., Orsière T. 2017. Fine atmospheric particles emitted by industrial, traffic and urban sources in France : characterization and genotoxicity. Toxicological and Environmental Chemistry, 99(2) : 340-362.

Bordier C., Suchail S., Pioz M., Devaud J.M., Collet C., Charreton M., Le Conte Y., Alaux C. 2017. Stress response in honeybees is associated to changes in task-related physiology and energetic metabolism. Journal of insect Physiology, 98:47-54, doi : 10.1016/j.jinsphys.2016.11.013

Castel P., Carcopino X., Robert S., Bonetto R., Cowen D., Orsiere T. 2017. The PIG- A gene, a new marker for mutagenesis. Médecine/Sciences, 33:432-439, doi : 10.1051/medsci/20173304014

Champarnaud A., Courbiere B., Perrin J., Bretelle F., Sari-Minodier I. 2017. Professional risks and pregnancy for hairdressers and estheticians : An inquiry about their practice with occupational physicians. Archives des Maladies Professionnelles et de L’Environnement, 78:485-497, doi : 10.1016/j.admp.2017.05.007

Dayras P., Charmantier G., Chaumot A., Vigneron A., Coquery M., Queau H., Artells E., Lignot J.H., Geffard O., Issartel J. 2017. Osmoregulatory responses to cadmium in reference and historically metal contaminated Gammarus fossarum (Crustacea, Amphipoda) populations. Chemosphere, 180:412-422, doi : 10.1016/j.chemosphere.2017.04.016

Elkhatib R.A., Paci M., Boissier R., Longepied G., Auguste Y., Achard V., Bourgeois P., Levy N., Branger N., Mitchell M.J., Metzler-Guillemain C. 2017. LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist. Reproduction 154:387-401, doi : 10.1530/rep-17-0358

Elkhatib R.A, Paci M., Longepied G., Saias-Magnan J., Courbiere B., Guichaoua M.R., Levy N., Metzler-Guillemain C., Mitchell M.J. 2017. Homozygous deletion of SUN5 in three men with decapitated spermatozoa. Human Molecular Genetics, 26:3167-3171, doi : 10.1093/hmg/ddx200

Fabregue A., Moheng B., Laynet A., Agostini A., Boubli L., Courbiere B. 2017. Parental project of general medicine residents from Aix-Marseille University : Theoretical knowledge in reproduction and behavior towards parenting. Journal of Gynecology Obstetrics and Human Reproduction, 46:261-266, doi : 10.1016/j.jogoh.2016.10.003

Garayev E., Herbette G., Di Giorgio C., Chiffolleau P., Roux D., Sallanon H., Ollivier E., Elias R., Baghdikian B. 2017 New sesquiterpene acid and inositol derivatives from Inula montana L. Fitoterapia, 120 : 79-84.

Lassalzede T., Paci M., Rouzier J., Carez S., Gnisci A., Saias-Magnan J., Deveze C., Perrin J., Metzler-Guillemain C. 2017. Sperm donor conception and disclosure to children : a 10-year retrospective follow-up study of parental attitudes in one French center for the study and preservation of eggs and sperm (CECOS). Fertility and Sterility, 108:247-253, doi : 10.1016/j.fertnstert.2017.06.001

Manasfi T., De Méo M., Di Giorgio C., Coulomb B., Boudenne J.L. 2017. Assessing the genotoxicity of two commonly occurring byproducts of water disinfection : Chloral hydrate and bromal hydrate. Mutation Research, 813 : 37-44.

Marchessaux G., Gadreaud J., Martin-Garin B., Thiéry A., Ourgaud M., Belloni B., Thibault D. 2017. First report of the invasive jellyfish Gonionemus vertens A. Agassiz, 1862 in the Berre Lagoon, southeast France. BioInvasions Records, 6:339-344, doi : 10.3391/bir.2017.6.4.06

Mathias F., Kabri Y., Okdah L., Di Giorgio C., Rolain J.M., Spitz C., Crozet M.D., Vanelle P. 2017. An efficient one-pot catalyzed synthesis of 2,4-disubstituted 5-nitroimidazoles displaying antiparasitic and antibacterial activities. Molecules, 22(8) : 1278.

Mortier I., Blanc J., Tosello B., Gire C., Bretelle F., Carcopino X. 2017. Is gestational diabetes an independent risk factor of neonatal severe respiratory distress syndrome after 34 weeks of gestation ? A prospective study. Archives of Gynecology and Obstetrics, 296:1071-1077, doi : 10.1007/s00404-017-4505-7

Nisse C., Barbeau D., Brunet D., El Yamani M., Fontaine B., Goujon Y., Labat L., Maitre A., Pillière F., Sari-Minodier I., Villa A., Garnier R. 2017. Recommandations de bonne pratique pour la surveillance biologique de l’exposition professionnelle aux agents chimiques (SBEP) : recommandations de la Société française de médecine du travail, associée à la Société française de toxicologie analytique et à la Société de toxicologie clinique. Toxicologie Analytique et Clinique, 29:351-376, doi : 10.1016/j.toxac.2017.05.001

Ohannessian A., Loundou A., Gnisci A., Paulmyer-Lacroix O., Perrin J., Courbiere B. 2017. Unexplained infertility : live-birth’s prognostic factors to determine the ART management. Minerva Ginecologica,

Paci M., Elkhatib R.A., Longepied G., Hennebicq S., Bessonat J., Courbiere B., Bourgeois P., Levy N., Mitchell M.J., Metzler-Guillemain C. 2017. Abnormal retention of nuclear lamina and disorganization of chromatin-related proteins in spermatozoa from DPY19L2-deleted globozoospermic patients. Reproductive BioMedicine Online, 35:562-570, doi : 10.1016/j.rbmo.2017.07.013

Rolland L., Courbiere B., Tassistro V., Sansoni A., Orsière T., Liu W., Di Giorgio C., Perrin J. 2017. Comet assay on thawed embryos : An optimized technique to evaluate DNA damage in mouse embryos. Toxicology In Vitro, 44 : 266-272.

Rolland L., Perrin J., Villes V., Pellegrin V., Boubli L., Courbiere B. 2017. IVF oocyte retrieval : prospective evaluation of the type of anesthesia on live birth rate, pain, and patient satisfaction. Journal of Assisted Reproduction and Genetics, 34:1523-1528, doi : 10.1007/s10815-017-1002-7

Roux P., Perrin J., Mancini J., Agostini A., Boubli L., Courbiere B. 2017. Factors associated with a poor prognosis for the IVF-ICSI live birth rate in women with rAFS stage III and IV endometriosis. Journal of Assisted Reproduction and Genetics, 4(7):921-928. doi : 10.1007/s10815-017-0943-1

Vincent-Hubert F., Uher E., Di Giorgio C., Michel C., De Méo M., Gourlay-France C. 2017. Use of low density polyethylene membranes for assessment of genotoxicity of PAHs in the Seine River. Ecotoxicology, 26(2) : 165-172.

Wilhelm S., Henneberg A., Köhler H.R., Rault M., Richter D., Scheurer M., Suchail S., Triebskorn R. 2017. Does wastewater treatment plant upgrading with activated carbon result in an improvement of fish health ? Aquatic Toxicology, 192:184-197, doi : 10.1016/j.aquatox.2017.09.017



Belliardo C., Gallice P., Chaspoul F., Correard F., Bergé-Lefranc D. 2016. Effect of Ni(II), Cd(II) and Al(III) on human fibroblast bioenergetics, a preliminary comparative study. Journal of Thermal Analysis and Calorimetry, 123:2543-2547, doi : 10.1007/s10973-016-5289-x

De Jong L., Pech N., Umbuzeiro G.A., Moreau X. 2016. Multi-scale biomarker evaluation of the toxicity of a commercial azo dye (Disperse Red 1) in an animal model, the freshwater cnidarian Hydra attenuata. Water Research, 96 : 62-73.

Manasfi T., De Méo M., Coulomb B., Di Giorgio C., Boudenne J.L. 2016. Identification of disinfection by-products in freshwater and seawater swimming pools and evaluation of genotoxicity. Environment International, 88 : 94-102.

Mostepha M., Sauzet C., Piccerelle P., Cau P., Levy N., Gallice P., Berge-Lefranc D. 2016. Treatment of a mastoid defect by free anterolateral thigh flap. European Annals of Otorhinolaryngology, Head and Neck Diseases, 133(3):195-198. doi : 10.1016/j.anorl.2015.08.034


Achouri D., Sergent M., Tonetto A., Piccerelle P., Andrieu V., Hornebecq V. 2015. Self-assembled liquid crystalline nanoparticles as an ophthalmic drug delivery system. Part II : optimization of formulation variables using experimental design. Drug Development and Industrial Pharmacy, 41(3) : 493-501.


El Hosry L., Di Giorgio C., Birer C., Habib J., Tueni M., Bun S.S., Herbette G., De Meo M., Ollivier E., Elias R. 2014. In vitro cytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated from Cyclamen persicum and Cyclamen libanoticum. Pharmaceutical Biology : 1–7. (doi:10.3109/13880209.2013.879600). Posted online on 20 Mar 2014.

Moreau X., De Jong L., Wafo E., Chaspoul F. 2014. Mise au point de la quantification d’un marqueur précoce de stress cellulaire chez les larves aquatiques de Cloeon dipterum (Ephemeroptera, Baetidae) collectées en région Méditerranéenne. Études vauclusiennes, 82 : 85-92.

Njock Makon S., Fouchier F., Seree E., Villard P.H., Landrier J.F., Pechere L., Barra Y., and Champion S. 2014. Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes. Mediators of Inflammation, Vol. 2014, Article ID 507272, 12 pages

Saez G., Aye M., De Meo M., Aimé A., Bestel I., Barthélémy P., Di Giorgio C. 2014. Genotoxic and oxidative responses in coelomocytes of Eisenia fetida and Hediste diversicolor exposed to lipid-coated CdSe/ZnS quantum dots and CdCl2. Environ Toxicol. doi : 10.1002/tox.21966. Posted online on 05 Feb 2014.

Roustan A., Aye M., De Meo M., Di Giorgio M. 2014. Genotoxicity of mixtures of glyphosate and atrazine and their environmental transformation products before and after photoactivation. Chemosphere, 108:93-100. doi : 10.1016/j.chemosphere

Wafo E., Risoul V., Schembri T., Lagadec V., Mama C., Boissery P., Portugal P., Dhermain F. 2014. Methylmercury and trace element distribution in the organs of Stenella coeruleoalba dolphins stranded on the French Mediterranean coast. Open Environmental Sciences. 8:35-48.


Achouri D., Hornebecq V., Piccerelle P., Andrieu V., Sergent M. 2013. Self-assembled liquid crystalline nanoparticles as an ophthalmic drug delivery system. Part I : influence of process parameters on their preparation studied by experimental design. Drug Development and Industrial Pharmacy (doi:10.3109/03639045.2013.850707)

Alhanout K., Di Giorgio C., De Méo M., Brunel J.-M. 2013. Non-genotoxic assessment of a natural antimicrobial agent : squalamine. Anti-Infective Agents in Medicinal Chemistry, 11(2) : 1-5.

Aye M., Di Giorgio C., Berque-Bestel I., Aime A., Pichon B.P., Jammes Y., Barthélémy P., De Méo M. 2013. Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots. Mutation research, 750(1-2):129-38.

Aye M., Di Giorgio C., Mekaouche M., Steinberg J.G., Brerro-Saby C., Barthélémy P., De Méo M., Jammes Y.. 2013. Genotoxicity of intraperitoneal injection of lipoamphiphile CdSe/ZnS quantum dots in rats. Mutation research, 758(1-2):48-55

Berthelot-Ricou A., Perrin J., Di Giorgio C., De Méo M., Botta A.,Courbiere B. 2013. Genotoxicity assessment of mouse oocytes by comet assay before vitrification and after warming with three vitrification protocols. Fertility and Sterility, 100(3):882-888.

Buendia-Jimenez I., Richardot P., Picard P., Talaska G., De Meo M., Friedlander G. 2013. P006 Effect of an increased water intake in DNA adducts formation and urinary mutagenicity in smokers : A randomised controlled trial. European Urology Supplements, 12(6):133.

Briand M.J., Letourneur Y., Bonnet X., Wafo E., Fauvel T., Brischoux F., Guillou G., Bustamante P. 2013. Spatial variability of metallic and organic contamination of anguilliform fish in New Caledonia. Environmental Science and Pollution Research, ISSN : 0944-1344 (Print) 1614-7499 (Online)

Cantecor B, Savelli M.P., Marti-Mestres G., Bonniol V., Mostefa Side Larbi M.A., Piccerelle, P. 2013. Recent Advances in Topical Applications for a New Anti-Aging Drug. In : R. Chilcott and K. R. Brain, Eds., Advances in Dermatological Sciences, Royal Society of Chemistry, London.

Cantecor B, Savelli M.P., Piccerelle P., Lévy N. 2013. Anti-aging efficacy of a new alendronate-pravastatin cosmetic combination : a randomized double blind comparative study. Journal of Cosmetics, Dermatological Sciences and Applications, 3:163-171.

Champion S., Sauzet C., Bremond P., Benbrahim K., Abraldes J., Seree E, Barra T., Villard P.H. 2013. Inflammation enhances AhR expression in intestinal cells through the NFκB pathway. ISRN Toxicology, Article ID 792452, 7 pages.

De Jong L., Moreau X., Bestel I., Beaudoin E., Aimé A., Dolain C., G. Saez G., Tonetto A., Barthélémy P., Thiéry A. 2013. Uptake of quantum dots into a freshwater flatworm : intracellular accumulation and transmission from parents to offspring. Journal of Nanoscience Letters, 3, 28.


Aye M., Di Giorgio C., Berque-Bestel I., Aime A. , Pichon B.P., Jammes Y., P. Barthélemy, De Méo M. 2012. Genotoxic and mutageneic effects of lipid-coated CdSe/ZnS quantum dots. Mutation Res. (E-pub ahead of print).

Liu W., Chaurand P., Di Giorgio C., De Meo M., Thill A., Auffan M., Masion A., Borschneck D., Chaspoul F. , Gallice P. , Botta A. , Bottero J.Y., Rose J.C. 2012. Influence of the length of imogolite-like nanotubes on their cytotoxicity and genotoxicity towards human dermal cells. Chem. Res. Toxicol., 25, 2513 .

Masotti V., De Jong L., Moreau X., Rabier J., Laffont-Schwob I., Thiéry A. 2012. Larvicidal activity of extracts from Artemisia species against Culex pipiens L. mosquito : comparing endemic versus ubiquist species for effectiveness. Comptes rendus biologies, 335(1):19-25

Mesnier A., Villard P.H., Nalbone G. 2012. PCB, diabète de type 2 et obésité : Approches cellulaire, moléculaire et expérimentale de l’effet des polychlorobiphényles (PCB) sur la biologie de l’adipocyte : implications dans le diabète et l’obésité. Les Cahiers de la Recherche Santé, Environnement, Travail (édition Anses), Décembre 2012, 16-18.

Rigaud S., Di Giorgio C. , Radakovitch O., Garnier J.M. , De Méo M. 2012. Genotoxicity of sediment extracts of the Berre Lagoon (France). Chemosphere (E-pub ahead of print).

Thiéry A., De Jong L., Issartel J., Moreau X., Saez G., Barthélémy P., Bestel I., Santaella C., Achouak W., Auffan M., Rose J. 2012. Effects of metallic and metal oxide nanoparticles in aquatic and terrestrial food chains. Biomarkers responses in invertebrates and bacteria. International Journal of Nanotechnology, 9:181-203.