Carole Di Giorgio

Titre

Institut Méditerranéen de Biodiversité et d’Écologie Marine et Continentale (IMBE)
UMR IMBE | Aix Marseille Université, CNRS, IRD, Avignon Université
Campus

Adresse

Courriel

Biosketch

Maitre de conférences à la faculté de pharmacie, responsable du laboratoire de mutagénèse environnementale

Membre de l’IMBE depuis 2015 dans l’équipe BES

Thématiques de recherche :
Etude du potentiel génotoxique des molécules naturelles et de synthèse, étude du potentiel génotoxique des polluants environnementaux et des matrices environnementales (eau, atmosphère, sédiments), étude de l’impact génotoxique de la pollution sur des espèces sentinelles

CV

Carole Di Giorgio, Ph.D, HDR
Institut Méditerranéen de Biodiversité et d’Ecologie marine et terrestre (IMBE)
Aix Marseille Université, UMR CNRS 7263 / IRD 237, Avignon Université
Faculté de Médecine, 27, Bd Jean Moulin, 13005 Marseille - France
Tel : (+33) 0 36 58 19 91 ; email : carole.di-giorio@univ-amu.fr

TITRES UNIVERSITAIRES

2001 : Habilitation à Diriger les Recherches
1992 : Doctorat de l’Université de la Méditerranée (Aix-Marseille II),
1986 : Diplôme d’ingénieur en microbiologie industrielle et appliquée

EXPERIENCES PROFESSIONNELLES

1995 : Maitre de conférences, faculté de Pharmacie, Marseille

Publications

1. Di Giorgio C., Botta A. Cobalt chloride induces micronuclei in human lymphocytes. Medical Science Research 1991, 19 : 219-220.
2. Di Giorgio C., Botta A., De Méo M.P., Laget M., Duménil G. Application du test de numération des micronoyaux aux lymphocytes de 100 sujets : étude de la distribution et des facteurs de variation. Annales de Biologie Clinique 1992, 1 : 1-4.
3. Di Giorgio C., De Méo M.P., Laget M., Guiraud H. , Duménil G. The micronucleus assay in human lymphocytes : screening for interindividual variability and application to biomonitoring. Carcinogenesis 1994, 15 : 313-317.
4. Di Giorgio C, Krempf A, Dumenil G, Tiret C, Binder B. Atmospheric microbial contamination in Marseilles and Porquerolles. Journal of Aerosol Science 1994, 25 : 187-188
5. Lehucher M.P., Di Giorgio C., Laget M., Aït Amara Y., Botta A. The micronucleus assay in exfoliated urothelial cells : effect of smoking. Mutagenesis 1995, 10 : 329-332.
6. Di Giorgio C., Krempf A., Guiraud H., Binder T., Tiret C. and Duménil G. Atmospheric contamination by airborne microorganisms in the city of Marseilles. Atmospheric Environment 1996, 30 : 155-160.
7. De Méo M.P., Laget M., Di Giorgio C., Guiraud H., Botta A., Castegnaro M. and Duménil G. Optimization of the Salmonella microsome assay (Ames test) for urine mutagenesis by experimental designs. Mutation Research 1996, 340 : 51-65.
8. De Méo M.P., Di Giorgio C, Marzin D, Jacquemont MC., Klein F, Haguenoer J.M. Biological monitoring of coke oven workers using the Ames test in urine. Relationship with urinary 1-hydroxypyrene. Mutation Research 1996, 360 : 241-242
9. Azas N., Di Giorgio C., Delmas F., Gasquet M. and Timon-David P. Assessment of amphotericin B susceptibility in Leishmania infantum promastigotes by flow cytometric membrane potential assay. Cytometry 1997, 28, 165-167
10. Azas N., Di Giorgio C., Delmas F., Gasquet M. and Timon-David P. Leishmania infantum promastigotes : flow cytometry as a possible tool for assessing the effects of drugs on cellular functions. Experimental Parasitology, 1997, 87, 1-7.
11. Azas N., Di Giorgio C., Gasquet M., Delmas F. and Timon-David P. Leishmania infantum promastigotes : effects of diamidines on DNA synthesis and non-protein thiol contents..Medical Science Research , 1999, 27.3, 149-152.
12. Di Giorgio C., Faraut-Gambarelli F., Imbert A., Gasquet M., Minodier P. and Dumon H. Flow cytometric assessment of amphotericin B-susceptibility in strains of leishmania infantum isolated from patients with visceral leishmaniasis. Journal of Antimicrobial Chemotherapy, 1999, 44, 71-76.
13. Traore-Keita F., Gasquet M., Di Giorgio C., Ollivier E., Delmas F., Keita A., Doumbo O., Balansard G. and Timon-David P. Antimalarial activity of four plants used in traditional medicine in Mali. Phytotherapy Research 2000, 14, 45-47.
14. Delmas F., Di Giorgio C, Elias R., Gasquet M., Azas N., Mshildadze V., Dekanosidze G., Kemertelidze E., and Timon-David P. Antileishmanial activity of three saponins isolated from ivy, hederinhederin and hederacolchicosid A’, as compared to their action on mammalian cells cultured in vitro. Planta Medica 2000, 66, 1-5.
15. Traore-Keita F., Gasquet M., Laget M., Guiraud H., Di Giorgio C., Azas N., Doumbo O. and Timon-David P. Toxicity and genotoxicity of antimalarial alkaloids extracted from Mitragyna inermis and Nauclea latifolia, Phytoterapy Research 2000, 14, 608-611.
16. Di Giorgio C., Ridoux O., Delmas F., Azas N., Gasquet M. and P. Timon-David. Flow cytometric detection of intracellular Leishmania parasites in human monocyte-derived macrophages. Antimicrobial Agents and Chemotherapy 2000, 44 (11), 3074-3078.
17. Ridoux O., Di Giorgio C., Delmas F., Elias R., Mshildadze G., Kemertelidze E, Balansard G and P. Timon-David. In vitro activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1 in association with pentamidine and amphotericin B. Phytotherapy Research, 2001, 15 : 298-301.
18. Azas N., Di Giorgio C., Delmas F., Gasquet M. and P. Timon-David. No evidence of oxidant events in amphotericin B cytotoxicity versus L. infantum promastigotes. Parasite, 2001, 8 : 335-339.
19. Azas N., Laurencin N., Delmas F., Di Giorgio C., Gasquet M. and P. Timon-David. Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali. Parasitology Research, 2002, 88 : 165-171.
20. Ancolio C., Azas N., Mahiou V., Ollivier E., Di Giorgio C., Keita A., Timon-David P. and Balansard G. Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome. Phytotherapy research, 2002, 16 : 646-649
21. Delmas F, Di Giorgio C., Robin M, Azas N., Gasquet M, Detang C, Costa M., Timon David P and Galy J-P. In vitro activity of position 2 substitution bearing 6-nitro- and 6-amino- benzothiazoles and their corresponding anthranilic acid derivatives against parasites of the species Leishmania infantum and Trichomonas vaginalis. Antimicrobial Agents and Chemotherapy, 2002, 46 : 2588-2594 .
22. Rathelot P, Azas N, El-Kashef H, Delmas F, Di Giorgio C, Timon-David P, Maldonado J and Vanelle P. 1,3-Diphenylpyrazoles : synthesis and antiparasitic activities of azomethine derivatives. European Journal of Medicinal Chemistry, 2002, 37 : 671-679.
23. Abdala H, Alvarez N, Delmas F, Di Giorgio C, Robert JM, Le baut G and Le Pape P. In vitro and In vivo antileishmanial activity of 2-amino-4,6-dimethylpyridine derivatives against Leishmania mexicana. Parasite, 2002, 9 : 367-370.
24. Di Giorgio C., Delmas F., Robin M., Seferian L., Azas N, Gasquet M., Costa M, P. Timon-David and J.P. Galy . In vitro antileishmanial activity of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes towards parasites of the species Leishmania infantum. Antimicrobial Agents and Chemotherapy, 2003, 47 : 174-180.
25. Azas N, Rathelot P, Djekou S, Delmas F, Gellis A, Di Giorgio C, Vanelle P and Timon-David P. Antiparasitic activity of highly conjugated pyrimidine –2-4-dione derivatives. Il Farmaco, 2003, 58, 1263-1270.
26. Hout S, Azas N, Darque A, Robin M, Di Giorgio C, Gasquet M, Galy J, Timon-David P. Activity of benzothiazoles and chemical derivatives on Plasmodium falciparum. Parasitology. 2004, 129:525-35.
27. Di Giorgio C., Delmas F., Ollivier E, Elias R. Timon-David. In vitro antileishmanial activity of the beta-carbolines harmane, harmine and harmaline towards parasites of the species L. infantum. Experimental Parasitology 2004, 106 : 67-74
28. Delmas F., Avellaneda A, Di Giorgio C, Robin M., De Clercq E., Pierre Timon-David P.,Galy JP. Synthesis and antileishmanial activities of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives. European Journal of Medicinal Chemistry 2004, 39 : 685-690
29. Di Giorgio C., Delmas F., Akhmedjanova V, Ollivier E, Bessonova I, Riad E and P. Timon-David. In vitro Antileishmanial activity of Diphyllin isolated from Haplophyllum bucharicum Planta Medica, 2005, 71 : 366-369.
30. Lamidi M., Di Giorgio C., Delmas F., Favel A., Eyele Mve Mba C., Rondi M, Ollivier E., Nze-Ekekang L and G Balansard. In vitro cytotoxic, Antileishmanial and antifungal activities of ethnopharmacologically selected Gabonese plants. J. Ethnopharmacology
31. Di Giorgio C., De Méo M, Chiron J, Delmas F, Nikoyan A, Jean S, Dumenil Gérard, Timon-David Pierre and Galy Jean-Pierre. Synthesis and antileishmanial activities of 4,5-di-substituted acridines as compared to their 4-mono-substituted homologues. Bioorganic and Medicinal Chemistry, 2005, 13 : 5560-5568.
32. Di Giorgio C., Lamidi Marou, Delmas Florence, Balansard Guy, Ollivier Evelyne. Antileishmanial activity of quinovic acid glycosides and cadambine acid isolated from Nauclea diderrichii. Planta Medica, 2006, 72 : 1396-1402.
33. Di Giorgio C., Shimi K, Boyer G, Delmas F and JP Galy. Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine. European Journal of medicinal Chemistry, 2007, 42 : 1277-1284.
34. Di Giorgio, C., Nikoyan, A., Decome, L., Botta, C., Robon, M., Reboul, J.P., Sabatier, A.S., Matta, A. and De Méo, M. 2008. DNA-damaging activity and mutagenicity of 16 newly synthesized thiazolo[5,4-a]acridine derivatives with high photo-inducible antitumoral activity. Mutation Res. 2008, 650 : 104-114.
35. Aouadene, A, C. Di Giorgio, L. Sarrazin, X. Moreau, L. De Jong, F. Garcia, A. Thiery, A. Botta and M. De Méo.. Evaluation of the genotoxicity of river sediments from industrialized and unaffected areas using a battery of short-term bioassays. Environ. Mol. Mutagen. 2008, 49 : 283-299.
36. Botta, C. C. Di Giorgio, A.S. Sabatier and M. De Méo. Genotoxicity of visible light (400-800 nm) and photoprotection assessment of three antioxidants and four sunscreens. J. Photochem. Photobiol. B, 2008. 25 : 24-34.
37. Di Giorgio C, Delmas F, Tueni M, Cheble E, Khalil T, Balansard G. 2008. Alternative and complementary antileishmanial treatments : assessment of the antileishmanial activity of 27 Lebanese plants, including 11 endemic species. J Altern Complement Med. 2008 14:157-62.
38. Botta C, Di Giorgio C, Sabatier AS, De Méo M. Effects of UVA and visible light on the photogenotoxicity of benzo[a]pyrene and pyrene. Environ Toxicol. 2008 Nov 10.
39. Benchabane Y, Di Giorgio C, Boyer G, Sabatier AS, Allegro D, Peyrot V, De Meo MP. Photo-inducible cytotoxic and clastogenic activities of 3,6-di-substituted acridines obtained by acylation of proflavine. Eur. J. Med. Chem. 2009. 44 : 2459–2467
40. Di Giorgio C, Liu W1, Sarrazin L, Wafo E, Moreau X, De Jong L, Thiery A, De Méo MP. Organic pollution and genotoxicity of sediments of the Palun Marshes (Berre Lagoon, France). J. Env. Qual. 2010, 39 : 2 : 558-567
41. Mustafayeva K, Di Giorgio C, Elias R, Kerimov Y, Ollivier E, De Méo MP.. DNA-damaging, mutagenic and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots. J. Nat. Prod. 2010, 73 : 99-103.
42. Aye M., Di Giorgio C., De Méo MP, Botta A., Perrin J., Courbiere B. Assessment of the genotoxicity of three cryoprotectants used for human oocyte vitrification : Dimethylulfoxide, ethylene glycol and propylene glycol. Food and Chem Toxicol. 2010, 48 : 1905-1912.
43. Saez G, Moreau X, De Jong L, Thiery A, Dolain C, Bestel I, Di Giorgio C, De Meo M, Barthélémy P. Development of new nano-tools : Towards an integrative approach to address the societal question of nanotechnology ? Nanotoday 2010, 5 : 251-253
44. Berthelot-Ricou A., Perrin J., Di Giorgio C., De Meo M., Botta A., Courbiere B.
Comet assay on mouse oocytes : an improved technique to evaluate genotoxic risk on female germ cells.
Fertility and Sterility, Fertil Steril. 2011, 95:1452-7.
45. Liu W, Di Giorgio C, Lamidi M, Elias R, Ollivier E, De Méo MP. Genotoxic and clastogenic activity of saponins extracted from Nauclea bark as assessed by the micronucleus and the comet assays in Chinese Hamster Ovary cells. J Ethnopharmacol. 2011 May 10. 2011 Sep 1 ;137(1):176-83. Epub 2011 May 10.
46. Di Giorgio C, Malleret L, Gueydon-Morin C, Rigaud S, De Méo M. Comparison of two extraction procedures for the assessment of sediment genotoxicity : Implication of polar organic compounds. Mutat Res. 2011 Oct 9 ;725(1-2):1-12. Epub 2011 Jul 27.
47. Di Giorgio C, Benchabane Y, Boyer G, Piccerelle P, De Méo M. Evaluation of the mutagenic/clastogenic potential of 3,6-di-substituted acridines targeted for anticancer chemotherapy. Food Chem Toxicol. 2011 Jul 23. [Epub ahead of print]
48. Berthelot-Ricou A, Perrin J, di Giorgio C, de Meo M, Botta A, Courbiere B. Assessment of 1,2-propanediol (PrOH) genotoxicity on mouse oocytes by comet assay. Fertil Steril. 2011 Sep 2. [Epub ahead of print]
49. Rigaud S, Di Giorgio C, Radakovitch O, Garnier JM, Méo MD. Genotoxicity of sediment extracts of the Berre lagoon (France). Chemosphere. 2012 Aug ;88(8):937-44. Epub 2012 Apr 7
50. Aye M, Di Giorgio C, Berque-Bestel I, Aime A, Pichon BP, Jammes Y, Barthélémy P, De Méo M.Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots. Mutat Res. 2013 750(1-2):129-38.
51. Liu W, Chaurand P, Di Giorgio C, De Méo M, Thill A, Auffan M, Masion A, Borschneck D, Chaspoul F, Gallice P, Botta A, Bottero JY, Rose J. Influence of the length of imogolite-like nanotubes on their cytotoxicity and genotoxicity toward human dermal cells. Chem Res Toxicol. 2012 Nov 19 ;25(11):2513-22.
52. Berthelot-Ricou A, Perrin J, di Giorgio C, de Meo M, Botta A, Courbiere B.Genotoxicity assessment of mouse oocytes by comet assay before vitrification and after warming with three vitrification protocols.vFertil Steril. 2013 Sep ;100(3):882-8.
53. Kamel Alhanout, Carole Di Giorgio, Michel De Méo and Jean Michel Brunel. Non-genotoxic assessment of a natural antimicrobial agent : squalamine. Anti infective agents
54. Aye M, Di Giorgio C, Mekaouche M, Steinberg JG, Brerro-Saby C, Barthélémy P, De Méo M, Jammes Y. Genotoxicity of intraperitoneal injection of lipoamphiphile CdSe/ZnS quantum dots in rats. Mutat Res. 2013 Dec 12 ;758(1-2):48-55.
55. Kamel Alhanout, Carole Di Giorgio, Michel De Méo and Jean M. Brunel. Non-Genotoxic Assessment of a Natural Antimicrobial Agent : Squalamine. Anti-Infective Agents, 2014, 12, 75-79
56. Saez G, Aye M, De Meo M, Aimé A, Bestel I, Barthélémy P, Di Giorgio C. Genotoxic and oxidative responses in coelomocytes of Eisenia fetida and Hediste diversicolor exposed to lipid-coated CdSe/ZnS quantum dots and CdCl2. Environ Toxicol. 2014 Feb 5. doi : 10.1002/tox.21966.
57. El Hosry L, Di Giorgio C, Birer C, Habib J, Tueni M, Bun SS, Herbette G, De Meo M, Ollivier E, Elias R.In vitro cytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated from Cyclamen persicum and Cyclamen libanoticum. Pharm Biol. 2014 Mar 20
58. Pieri C, Borselli D, Di Giorgio C, De Méo M, Bolla JM, Vidal N, Combes S, Brunel JM. New Ianthelliformisamine Derivatives as Antibiotic Enhancers against Resistant Gram-Negative Bacteria. J Med Chem. 2014 May 22 ;57(10):4263-72.
59. Roustan A, Aye M, De Meo M, Di Giorgio C. Genotoxicity of mixtures of glyphosate and atrazine and their environmental transformation products before and after photoactivation. Chemosphere. 2014 Aug ;108:93-100. doi : 10.1016/j.chemosphere.2014.02.079.
60. Di Giorgio C, Boyer L, De Meo M, Laurant C, Elias R, Ollivier E. In vitro and in vivo antimutagenic effects of DIG, a herbal preparation of Berberis vulgaris, Taraxacum officinale and Arctium lappa, against mitomycin C. J Nat Med. 2015 Feb 10.
61. Manasfi T, De Méo M, Coulomb B, Di Giorgio C, Boudenne JL. Identification of disinfection by-products in freshwater and seawater swimming pools and evaluation of genotoxicity. Environ Int. 2016 Mar ;88:94-102.
62. Vincent-Hubert F, Uher E, Di Giorgio C, Michel C, De Meo M, Gourlay-France C. Use of low density polyethylene membranes for assessment of genotoxicity of PAHs in the Seine River. Ecotoxicology. 2017 Mar ;26(2):165-172.
63. Manasfi T, De Méo M, Di Giorgio C, Coulomb B, Boudenne JL. Assessing the genotoxicity of two commonly occurring byproducts of water disinfection : Chloral hydrate and bromal hydrate. Mutat Res. 2017 Jan ;813:37-44.
64. Garayev E, Herbette G, Di Giorgio C, Chiffolleau P, Roux D, Sallanon H, Ollivier E, Elias R, Baghdikian B. New sesquiterpene acid and inositol derivatives from Inula montana L. Fitoterapia. 2017 Jul ;120:79-84.
65. Rolland L, Courbiere B, Tassistro V, Sansoni A, Orsière T, Liu W, Di Giorgio C, Perrin J. Comet assay on thawed embryos : An optimized technique to evaluate DNA damage in mouse embryos. Toxicol In Vitro. 2017 Oct ;44:266-272.
66. Mathias F, Kabri Y, Okdah L, Di Giorgio C, Rolain JM, Spitz C, Crozet MD, Vanelle P. An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities. Molecules. 2017 Aug 3 ;22(8). pii : E1278.
67. Brunel F, Lautard C, di Giorgio C, Garzino F, Raimundo JM, Bolla JM, Camplo M. Antibacterial activities of mono-, di- and tri-substituted triphenylamine-based phosphonium ionic liquids. Bioorg Med Chem Lett. 2018 Mar 1 ;28(5):926-929.
68. Blanchet M1, Borselli D2, Rodallec A1, Peiretti F3, Vidal N4, Bolla JM2, Di Giorgio C5, Morrison KR6, Wuest WM6, Brunel JM1. Claramines : A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity. Chem Med Chem. 2018 Feb 21. doi : 10.1002/cmdc.201800073.
69. Samy Iskandar a,b,*, Martial Senankpon Gnansounou a,b,c, Maxime Robin a,b, Jean Lorquin. Antioxidant, Anti-inflammatory and Neuroprotective Activities of a Plant Extract Derived from Traditional Chinese Medicine : SuHeXiang Wan (AT000). Chemistry of Advanced Materials 3(2) (2018) 36-59.
70. Da Costa L, Scheers E, Coluccia A, Casulli A, Roche M, Di Giorgio C, Neyts J, Terme T, Cirilli R, La Regina G, Silvestri R, Mirabelli C, Vanelle P. Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication. J Med Chem. 2018 Sep 7. doi : 10.1021/acs.jmedchem.8b00931. [Epub ahead of print]
71. Garayev E, Di Giorgio C, Herbette G, Mabrouki F, Chiffolleau P, Roux D, Sallanon H, Ollivier E, Elias R, Baghdikian B. Bioassay-guided isolation and UHPLC-DAD-ESI-MS/MS quantification of potential anti-inflammatory phenolic compounds from flowers of Inula montana L. J Ethnopharmacol. 2018 Nov 15 ;226:176-184.
72. Blanchet M, Borselli D, Rodallec A, Peiretti F, Vidal N, Bolla JM, Digiorgio C, Morrison KR, Wuest WM, Brunel JM. Claramines : A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity.ChemMedChem. 2018 May 23 ;13(10):1018-1027. doi : 10.1002/cmdc.201800073. Epub 2018 Apr 10.
73. Senankpon Martial Gnansounou, Samy Iskandar, Lydia Abou, Maxime Robin, Carole DI Giorgio, Edwige Dahouenon Ahoussi, Philippe Piccerelle and Dominique Koko Sonhounhloue. GC-MS screening and evaluation of the anti-inflammatory and antioxidant activities of ethanolic leaves and stem barks extracts from Dialium guineense Willd, Parkia biglobosa (Jacq.) R. Br. ex Benth. and Tamarindus indica L. J Pharmacognosy and phytochemistry. 2019, 8-1 : 295-301
74. Borazjani N, Sepehri S, Behzadi M, Jarrahpour A, Rad JA, Sasanipour M, Mohkam M, Ghasemi Y, Akbarizadeh AR, Digiorgio C, Brunel JM, Ghanbari MM, Batta G, Turos E. Three-component synthesis of chromeno β-lactam hybrids for inflammation and cancer screening. Eur J Med Chem. 2019 Oct 1 ;179:389-403. doi : 10.1016/j.ejmech.2019.06.036. Epub 2019 Jun 17.
75. Spitz C, Mathias F, Péchiné S, Doan THD, Innocent J, Pellissier S, Di Giorgio C, Crozet MD, Janoir C, Vanelle P. 2,4-Disubstituted 5-Nitroimidazoles Potent against Clostridium difficile. ChemMedChem. 2019 Jan 14. doi : 10.1002/cmdc.201800784.
76. Manasfi T, De Méo M, Coulomb B, Di Giorgio C, Ravier S, Boudenne JL. Development of transient mutagenic activity following the chlorination of the sunscreen UV filter dioxybenzone (benzophenone-8) in bromide-rich water. Int J Hyg Environ Health. 2019 Apr 16. pii : S1438-4639(18)30798-3. doi : 10.1016/j.ijheh.2019.04.003. [Epub ahead of print]
77. Fersing C, Boudot C, Paoli-Lombardo R, Primas N, Pinault E, Hutter S, Castera-Ducros C, Kabri Y, Pedron J, Bourgeade-Delmas S, Sournia-Saquet A, Stigliani JL, Valentin A, Azqueta A, Muruzabal D, Destere A, Wyllie S, Fairlamb AH, Corvaisier S, Since M, Malzert-Freon A, Di Giorgio C, Rathelot P, Azas N, Courtioux B, Vanelle P, Verhaeghe P 2020 Antikinetoplastid SAR study in 3-nitroimidazopyridine series : Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties. Eur J Med Chem 206:112668, doi:10.1016/j.ejmech.2020.112668
78. Heiran R, Sepehri S, Jarrahpour A, Di Giorgio C, Douafer H, Brunel JM, Gholami A, Riazimontazer E, Turos E 2020 Synthesis, docking and evaluation of in vitro anti-inflammatory activity of novel morpholine capped beta-lactam derivatives. Bioorg Chem 102:104091, doi : 10.1016/j.bioorg.2020.104091
79. Lorquin, F., Ziarelli, F., Amouric, A. et al. Production and properties of non-cytotoxic pyomelanin by laccase and comparison to bacterial and synthetic pigments. Sci Rep 11, 8538 (2021).
80. Chamayou-Robert C, DiGiorgio C, Brack O, Doucet O. Blue light induces DNA damage in normal human skin keratinocytes. Photodermatol Photoimmunol Photomed. 2021 Jul 15. doi : 10.1111/phpp.12718. Online ahead of print. PMID : 34265135
81. Lorquin F, Lorquin J, Claeys-Bruno M, Rollet M, Robin M, Di Giorgio C, Piccerelle P. Lignosulfonate is an efficient SPF booster : Application to eco-friendly sunscreen formulations. Sustainable Chemistry and Pharmacy 24 (2021) 100539