Post-doctoral researcher of the IMBE team 6 - Biomarkers, Environment, Health (BES), my research topics are focused on the impact that nanomaterials (NM) and nanoparticles (NP) dispersed in the environment have on human health.

The core of my studies is on DNA damage analysis (fragmentation, chromosome loss, mutagenesis, ...) that can potentially derive from occupational or accidental exposure to NMs and NPs, as well as on the mechanisms that induce genotoxicity (oxidative stress, internalization, apoptosis and necrosis, inflammation, ...).
I am also interested in the analysis of the physico-chemical properties of NMs and NPs throughout their entire life cycle, and on how these modification can affectNM and NP toxic potential.
I have also good skills in cytotoxicity and carcinogenesis, in microscopy and cytometry studies, using in vitro (2D and 3D) and ex vivo models.
I have worked with different types of NM and NP of atmospheric origin, or used as food and paints additives, or displaying antimicrobial and antifungal properties, or derived from thermonuclear fusion reactors.

Currently I am working on the development of a new in vitro mutagenesis test applicable to NP and aimed at monitoring and evaluating iatrogenic, occupational or environmental exposures.

I acquired my technical and scientific skills during my international mobility in Italy, Germany, Switzerland and France.

Member of the administration board of the French Society of Genetic Toxicology

Post-doctorates

• 2018 - onwards: team Biomarkers, Environment, Health - IMBE, campus Timone, Faculty of medical and paramedical sciences, Aix-Marseille University (Marseille, France)
• 2014 – 2016: team Biogenotoxicology, Human Health and Environment - IMBE, campus Timone, Faculty of Medicine, Aix-Marseille University (Marseille, France)
• 2013 – 2014: Medical Genetics unit, Faculty of Medicine, University of Pisa (Pisa, Italy)
• 2009 – 2012: Nanobiosciences unit, European Commission, Joint Research Centre (Ispra, Italy)
• 2006 – 2009: REPAIR-lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University (Mainz, Germany)

Doctorate

• 2004 – 2006: Theodor Kocher Institute, Faculty of Medicine, University of Bern (Bern, Switzerland)
• 2002 – 2004: Max Planck Institute for molecular biology (Münster, Germany)

Education

• 2006: Doctorate at the Westfälische Wilhelms-Universität (Münster, Germany)
• 2002: MSc at the Insubria University (Varese, Italy)

J’ai travaillé en tant que « work-package leader » lors de plusieurs projets européens. J’ai donc acquis une bonne maitrise en la rédaction de « milestones&deliverables » ainsi que de « progress reports ». Je maitrise aussi la rédaction de manuscrits pour de revues à comité de lecture internationale et la présentation de projets et des résultats sous forme orale et affichée

J’ai encadré plusieurs étudiants en stage de Licence, M1 et M2, et j’ai aussi coordonné les activités de plusieurs assistants techniques

Depuis 2018 je suis membre du conseil d’Administration de la Société Française de Toxicologie Génétique

Original research papers published in peer-reviewed journals

George I*, Uboldi C*, Bernard E, Sobrido MS, Dine S, Hagège A, Vrel D, Herlin N, Rose J, Orsière T, Grisolia C, Rousseau B, Malard V. Toxicological Assessment of ITER-Like Tungsten Nanoparticles Using an In Vitro 3D Human Airway Epithelium Model. Nanomaterials, 2019; 9(10). doi: 10.3390/nano9101374. * equally contributed

Uboldi C, Sanles Sobrido M, Bernard E, Tassistro V, Herlin-Boime N, Vrel D, Garcia-Argote S, Roche S, Magdinier F, Dinescu G, Malard V, Lebaron-Jacobs L, Rose J, Rousseau B, Delaporte P, Grisolia C, Orsière T. In vitro analysis of the effects of ITER-like tungsten nanoparticles : cytotoxicity and epigenotoxicity in BEAS-2B cells. Nanomaterials, 2019; 9(9):1233. doi: 10.3390/nano9091233.

Bernard E, Jambon F, Georges I, Sanles Sobrido M, Rose J, Herlin-Boime N, Miserque F, Beaunier P, Vrel D, Dine S, Hodille E, Chêne J, Garcia-Argote S, Pieters G, Peillon S, Gensdarmes F, Dinescu G, Acsente T, Uboldi C, Orsiere T, Malardv, Rousseau B, Dine G, Delaporte P, Grisoliac. Design of model tokamak particles for future toxicity studies: morphology and physical characterization. Fusion Engineering And Design, 2019; 145:60-65. doi: 10.1016/J.Fusengdes.2019.05.037.

Grisolia C, Gensdarmes F, Peillon S, Dougniaux G, Bernard E, Autricque A, Pieters G, Rousseau B, Feuillastre S, Garcia-Argote S, Carvalho S, Malard V, George I, Lebaron-Jacobs L, Orsière T, Uboldi C, Rose J, Senles M, Lambertin D, Vrel D, Decanis C, Liger K. Current investigations on tritiated dust and their impact on tokamak safety. Nucl. Fusion, 2019; 59:086061. https://doi.org/10.1088/1741-4326/ab1a76.

Malard V, Bresson C, Uboldi C, Delangle P, Van der Meeren A, Lemaire D, Darolles C, Orsière T, Ortega R, Berthomieu C. Toxicity mechanisms of cobalt oxide particles (Co3O4P) on human lung cells: impact of solubilization. BIO Web of Conferences, 2019; 14:05010.

Stoccoro A, Di Bucchianico S, Coppedè F, Ponti J, Uboldi C, Blosi M, Delpivo C, Ortelli S, Costa AL, Migliore L. Multiple endpoints to evaluate pristine and remediated titanium dioxide nanoparticles genotoxicity in lung epithelial A549 cells. Toxicology letters, 2017; 276:49-61.

Stoccoro A, Di Bucchianico S, Uboldi C, Coppedè F, Ponti J, Placidi C, Blosi M, Ortelli S, Costa AL and Migliore L. A panel of in vitro tests to evaluate genotoxic and morphological neoplastic transformation potential on Balb/3T3 cells by pristine and remediated titania and zirconia nanoparticles. Mutagenesis, 2016; 31(5):511-29. doi: 10.1093/mutage/gew015.

Choukourov A, Gordeev I, Ponti J, Uboldi C, Melnichuk I, Vaidulych M, Kousal J, Nikitin D, Hanyková L, Krakovský I, Slavínská D and Biederman H. Microphase-Separated PE/PEO Thin Films Prepared by Plasma-Assisted Vapor Phase Deposition. ACS Appl Mater Interfaces, 2016; 8(12):8201-12. doi: 10.1021/acsami.5b12382.

Uboldi C, Urbàn P, Ponti J, Bayak E, Valsami-Jones E, Gilliland D and Rossi F. Rutile titanium dioxide nanoparticles induce cytotoxicity and morphological transformation in Balb/3T3 cells. Toxicol in vitro, 2016; 31:137-45; doi: 10.1016/j.tiv.2015.11.005.

Uboldi C, Orsière T, Darolles C, Aloin V, Tassistro V, George I and Malard V. Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways. Part Fibre Toxicol, 2016; 13(1):5. doi: 10.1186/s12989-016-0118-8.

Migliore L, Uboldi C, Di Bucchianico S, Coppede F. Nanomaterials and neurodegeneration. Environ Molecular Mutagen, 2015; 56 (2):149-170. doi: 10.1002/em.21931.

Locatelli E, Naddaka M, Uboldi C, Loudos G, Fragogeorgi E, Molinari V, Pucci A, Tsotakos T, Psimadas D, Ponti J and Comes Franchini M. Targeted delivery of silver nanoparticles and Alisertib. In vitro and in vivo synergistic effect against glioblastoma. Nanomedicine, 2014; 9(6):839–849. doi: 10.2217/nnm.14.1.

Di Bucchianico S, Fabbrizi MR, Cirillo S, Uboldi C, Gilliland D, Valsami-Jones E and Migliore L. Aneuploidogenic effects and DNA oxidation induced in vitro by differently sized gold nanoparticles. Int J Nanomedicine, 2014; 9:2191–2204. doi: 10.2147/IJN.S58397.

Goñi-de-Cerio F, Mariani V, Cohen D, Madi L, Thevenot J, Oliveira H, Uboldi C, Giudetti G, Coradeghini R, Garanger E, Rossi F, Portugal-Cohen M, Oron M, Korenstein R, Lecommandoux S, Ponti J, Suárez-Merino B and Heredia P. Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity testing. J Nanopart Res, 2013; 15:2036. doi:10.1007/s11051-013-2036-0.

Horev-Azaria L, Korenstein R, Beno D, Bonacchi D, Baldi G, Golla-Schindler U, Sommer D, Kirkpatrick CJ, Unger RE, Uboldi C, Landsiedel R, Kolle S, Maimon O, Romano R, Villiers C, Marche P, Ponti J and Rossi F. Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data. Part Fibre Toxicol, 2013; 10:32. doi: 10.1186/1743-8977-10-32.

Pucci A, Locatelli E, Ponti J, Uboldi C, Molinari V and Comes Franchini M. Click Chemistry on the surface of PLGA-b-PEG polymeric nanoparticles: a novel targetable fluorescent imaging nanocarrier. J Nanopart Res, 2013; 15:1818. doi: 10.1007/s11051-013-1818-8.

Gianoncelli A, Marmorato P, Ponti J, Pascolo L, Kaulich B, Uboldi C, Rossi F, Makovec D, Kiskinova M and Ceccone G. Interaction Q2 of magnetic nanoparticles with U87MG cells studied by synchrotron radiation X-ray fluorescence techniques. X-Ray Spectrometry, 2013; 42(4):316-320. doi: 10.1002/xrs.2475.

De Angelis I, Barone F, Zijno A, Bizzarri L, Russo MT, Pozzi R, Franchini F, Giudetti G, Uboldi C, Ponti J, Rossi F and De Berardis B. Comparative study of toxicological effects induced by ZnO and TiO2 nanoparticles on human colon carcinoma cells. Nanotoxicology, 2013; 7(8):1361-1372. doi: 10.3109/17435390.2012.741724.

Freese C, Uboldi C, Gibson M, Klok HA, Unger RE and Kirkpatrick CJ. Uptake and cytotoxicity of gold nanoparticles: Effects on human endothelial cells and comparison with human epithelial cells. Part Fibre Toxicol, 2012; 9:23. doi: 10.1186/1743-8977-9-23.

Farcal LR, Uboldi C, Mehn D, Giudetti G, Nativo P, Ponti J, Gilliland D, Rossi F and Bal-Price A. Mechanisms of toxicity induced by SiO2 nanoparticles of in vitro human alveolar barrier: effects on cytokine production, oxidative stress induction, surfactant proteins A mRNA expression and nanoparticles uptake. Nanotoxicology, 2012; 7:1095-110. doi: 10.3109/17435390.2012.710658.

Uboldi C, Giudetti G, Broggi F, Gilliland D, Ponti J and Rossi F. Amorphous silica nanoparticles do not induce cytotoxicity, carcinogenicity nor genotoxicity in Balb/3T3 mouse fibroblasts. Mutat Res: Genet Toxicol Environ Mutagen, 2012; 745:11-20. doi: 10.1016/j.mrgentox.2011.10.010.

Horev-Azaria L, Kirkpatrick CJ, Korenstein R, Marche PN, Maimon O, Ponti J, Romano R, Rossi F, Golla-Schindler U, Sommer D, Uboldi C, Unger RE and Villiers C. Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data. Toxicol Sci, 2011; 122(2):489-501. doi: 10.1093/toxsci/kfr124.

Mittler F, Uboldi C, Delmas T, Broggi F, Boisseau P, Rossi F, Vinet F, Texier I, Ponti J, Navarro FP. Lipidots™: des nanoparticules biodégradables pour l’imagerie médicale et/ou la délivrance de médicaments. Materiaux 2010.

Ponti J, Colognato R, Franchini F, Gioria S, Simonelli F, Abbas K, Uboldi C, Kirkpatrick CJ, Holzwarth U and Rossi F. A quantitative in vitro approach to study the intracellular fate of gold nanoparticles: from synthesis to cytotoxicity. Nanotoxicology, 2009; 3(4):296–306. doi: 10.3109/17435390903056384.

Uboldi C, Bonacchi D, Lorenzi G, Hermanns MI, Pohl C, Baldi G, Unger RE and Kirkpatrick CJ. Gold nanoparticles induce in vitro cytotoxicity in the alveolar type-II cell lines A549 and NCIH441. Part Fibre Toxicol, 2009, 6:18. doi: 10.1186/1743-8977-6-18.

Hermanns MI, Kasper J, Dubruel P, Pohl C, Uboldi C, Vermeersch V, Fuchs S, Unger RE and Kirkpatrick CJ. An impaired alveolar-capillary barrier in vitro: effect of proinflammatory cytokines and consequences on nanocarrier interaction. J R Soc Interface, 2010; 7(Suppl1):S41-54. doi: 10.1098/rsif.2009.0288.focus.

Pohl C, Papritz M, Moisch M, Wübbecke C, Hermanns MI, Uboldi C, Dei-Anang J, Mayer E, Kirkpatrick CJ and Kehe K. Acute morphological and toxicological effects in a human bronchial co-culture model after Sulphur Mustard exposure. Toxicol Sci, 2009; 112(2):482-9. doi: 10.1093/toxsci/kfp211.

Pohl C, Hermanns MI, Uboldi C, Bock M, Fuchs S, Dei-Anang J, Mayer E, Kehe K, Kummer W and Kirkpatrick CJ. Barrier functions and paracellular integrity in human cell culture models of the proximal respiratory unit. Eur J Pharm Biopharm, 2009; 72(2):339-349. doi: 10.1016/j.ejpb.2008.07.012.

Uboldi C, Doering A, Alt C, Estess P, Siegelman M and Engelhardt B. L-Selectin-deficient SJL mice are not resistant to experimental autoimmune encephalomyelitis. Eur J Immunol, 2008; 38:2156-2167. doi: 10.1002/eji.200838209.

Abstracts published in peer-reviewed journals

George I, Hagège A, Herlin N, Vrel D, Rose J, Sanles M, Orsière T, Uboldi C, Grisolia C, Rousseau B, Malard V. Assessment of respiratory toxicity of ITER-like tungsten metal nanoparticles using an in vitro 3D human airway epithelium model. Toxicol Lett, 2015; 238(2): S179. doi:10.1016/j.toxlet.2015.08.519.

Uboldi C, Barth S, Unger RE, Kirkpatrick CJ. Surface modification influences the in vitro toxicity of gold nanoparticles in human alveolar type-II cell lines. ALTEX, 2008; 25 Suppl.1.

Engelhardt B, Uboldi C, Vestweber D, Döring A. Selectins and their ligands are not required for immune cell recruitment across the blood-brain barrier during experimental autoimmune encephalomyelitis. Swiss Medical Weekly, 2007; 137: 20S.

Hermanns MI, Dubruel P, Uboldi C, Schacht E and Kirkpatrick CJ. In vitro toxicity of polyethyleneimine nanoparticles on human distal lung cells in mono- and co-culture. ALTEX, 2007 ; 3/07: 199.

Uboldi C, Alt C, Estess P, Siegelman M, Engelhardt B. L-selectin-deficient mice develop experimental autoimmune encephalomyelitis. Swiss Medical Weekly, Supplément Mars 2006. Société Suisse d’Allergologie et d’Immunologie (SSAI).

Uboldi C, Siegelman M, Engelhardt B. L-selectin-deficient mice develop experimental autoimmune encephalomyelitis. Swiss Medical Weekly, Supplément Mars 2005. Société Suisse d’Allergologie et d’Immunologie (SSAI).

Book chapter

Migliore L, Di Bucchianico S and Uboldi C. The In Vitro Micronucleus Assay and FISH Analysis. 2014; Chapitre 5 de “Genotoxicity and DNA Repair. A practical approach”, série “Methods in Pharmacology and Toxicology”. Editors: L. María Sierra et Isabel Gaivão. Springer New York Publisher. ISSN: 1557-2153.

Doctorate and MSc

2006 Doctoral thesis : “SJL/L-selectin-deficient mice develop experimental autoimmune encephalomyelitis”
2002 MSc : “Tossicologia in vitro di metalli in tracce: studi con colture cellulari”

• Uboldi C, Tassistro V, Rober S, Dussert F, Carrière M and Orsière T. Development of a new test to assess the mutagenic potential of nanomaterials: the in vitro PIG-A assay. 47th European Environmental Mutagenesis and Genomics Society Meeting (19-23 mai 2019; Rennes, France).

• Uboldi C, Bernard E, George I, Sanles M, Roche S, Magdinier F, Rousseau B, Dinescu G, Herlin N, Lebaron-Jacobs L, Delaporte P, Vrel D, Rose J, Malard V, Grisolia C and Orsière T. Tritiated and non tritiated ITER-like tungsten particles in lung-derived cells: an epigenotoxic study. First Tritium School – TRANSAT H2020 project (25-28 Mars 2019; Ljubljana, Slovenie).

• Uboldi C, Dussert F, Tassistro V, Carrière M, Orsière T. Mutagénèse induite par les nanoparticules: criblage du test PIG-A in vitro sur l’Homme. Forum annuel de la Société Française de Toxicologie Génétique (1-2 octobre 2018; Paris, France).

• Uboldi C, Bernard E, George I, Sanles M, Roche S, Magdinier F, Rousseau B, Dinescu G, Herlin N, Lebaron-Jacobs L, Delaporte P, Vrel D, Rose J, Malard V, Grisolia C and Orsière T. Epigenotoxic investigation of tritiated and non tritated ITER-like tungsten particles in lung-derived cells: the PASSIV-ITER project. 11th International Particle Toxicology Conference (26-29 septembre 2016; Singapour).

• Uboldi C, Bernard E, George I, Sanles M, Roche S, Magdinier F, Rousseau B, Dinescu G, Herlin N, Lebaron-Jacobs L, Delaporte P, Vrel D, Rose J, Malard V, Grisolia C and Orsière T. ITER-like tritiated tungsten particles: cytotoxic and genotoxic effects in lung cells. Forum annuel de la Société Française de Toxicologie Génétique (23-24 juin 2016; Paris, France).

• Uboldi C, Bernard E, George I, Sanles M, Roche S, Magdinier F, Rousseau B, Dinescu G, Herlin N, Lebaron-Jacobs L, Delaporte P, Vrel D, Rose J, Malard V, Grisolia C and Orsière T. ITER-like tritiated tungsten particles: cytotoxic and genotoxic effects in lung cells. Journée Annuelle « Faits Marquants et Perspectives » du programme transversal Toxicologie du Commissariat à l’énergie atomique et aux énergies alternatives (CEA) (22 juin 2016; CEA Saclay, Gif-sur-Yvette, France).

• Uboldi C, Di Bucchianico S, Brunetti T, Luongo S., Coppedè F., Delpivo C., Costa A., Migliore L. A panel of tests to evaluate genotoxicity and carcinogenicity induced in vitro by metal oxide nanoparticles. XIII Congress of the Italian Federation of Life Sciences (24-27 septembre 2014; Pise, Italie).

• Kinsner-Ovaskainen A, Uboldi C, Cydzik I, Simonelli F, Alloa E, Ceridono M, Gilliland D, Ponti J, Rossi F. Assessment of cytotoxicity, intracellular uptake and intestinal absorption of amorphous silica nanoparticles in the Caco-2 in vitro human intestinal barrier model. NanoSafe 2012 (13-15 novembre 2012; Grenoble, France).

• Farcal LR, Uboldi C, Mehn D, Giudetti G, Nativo P, Ponti J, Gilliland D, Rossi F and Bal-Price A. The response of an in vitro human alveolar barrier to SiO2 nanoparticles exposure in the presence or absence of THP-1 monocytes. 9th International Conference and Workshop on Biological Barriers (29 février – 3 mars 2012; Sarrebruck, Allemagne).

• Uboldi C, Giudetti G, Broggi F, Ponti J, Gilliland D, and Rossi F. Assessment of the in vitro toxicological profile of amorphous silica nanoparticles and study of their intracellular fate. CELLTOX 1991-2011 Twenty years of in vitro toxicology: Achievements and future challenges (19-21 octobre 2011; Rome, Italie).

• Uboldi C, Giudetti G, Broggi F, Ponti J, Gilliland D, and Rossi F. Assessment of the in vitro toxicological profile of amorphous silica nanoparticles and study of their intracellular fate. SPP1313 Biological Responses to Nanoscale Nanoparticles (11-15 septembre 2011; Essen, Allemagne).

• Uboldi C, Ponti J, Giudetti G, Gilliland D, Rossi F, Calzolai L. Use of fluorescent amorphous silica to study the intracellular fate of nanoparticles and assessment of its in vitro toxicological profile. ICMAT - International Conference on Materials for Advanced Technologies (26 juin - 01 juillet 2011; Singapour).

• Uboldi C, Ponti J, Gilliland D, and Rossi F. Evaluation of the toxicity of manufactured nanomaterials by in vitro methods. 1st Italian-Swedish Workshop on Health Impacts of Engineered Nanoparticles (14-15 octobre 2010; Rome, Italie).

• Uboldi C. Nanoparticles-induced cytotoxicity in human alveolar cells. Invitée chez F.Hoffman-Roche (27 avril 2009; Bâle, Suisse).

• Uboldi C. Interaction of nanoparticles with an in vitro model of the human alveolo-capillary barrier. Invitée à l’Institut de biologie du poumon et Centre pour la recherche translationnelle du poumon, Helmholtz Zentrum (14 avril 2009; Munich, Allemagne).

• Uboldi C. Methods to assess nanoparticle uptake and traffic in cells. CellNanoTox 1st interdisciplinary workshop on novel methodologies for studying nanoparticles and their interaction with biomaterials (14 avril 2008; Ludwigshafen, Allemagne).

• Uboldi C, Hermanns I, Pohl C, Kirkpatrick CJ. In vitro co-culture models of the human proximal and distal respiratory unit. Centre for Nanotechnology (3 juin 2007; Münster, Allemagne).

• Uboldi C, Hermanns I, Kirkpatrick CJ. Co-culture models of the bronchial and air-blood barrier to study nanoparticles interaction. 3rd Nano2Life Conference (19-21 mars 2007; Sarrebruck, Allemagne).

• Uboldi C, Siegelman M, Engelhardt B. L-selectin-deficient mice develop experimental autoimmune encephalomyelitis. 3rd International Summer school in Immunology (14-16 août 2004; Champéry, Suisse).

• Uboldi C, Bernard E, Sanles Sobrido M, Roche S, Magdinier F, Delaporte P, Dinescu G, Herlin N, Lebaron-Jacobs L, Malard V, Rose J, Rousseau B, Vrel D, Grisolia C, Orsière T. Epigenotoxicity of tritiated and non tritiated ITER-like tungsten nanoparticles: effects on lung human-derived cells. 47th European Environmental Mutagenesis and Genomics Society Meeting (19-23 mai 2019; Rennes, France).

• Uboldi C, Dussert F, Tassistro V, Carriere M, Orsiere T. Mutagénèse induite par les nanoparticules: criblage du test PIG-A in vitro sur l’homme. Forum annuel de la société française de toxicologie génétique (1-2 octobre 2018; Paris, France).

• Uboldi C, Bernard E, George I, Sanles M, Roche S, Magdinier F, Rousseau B, Dinescu G, Herlin N, Lebaron-Jacobs L, Delaporte P, Vrel D, Rose J, Malard V, Grisolia C and Orsière T. From synthesis to epi-genotoxicity of tritiated and non tritated ITER-like tungsten microparticles: the PASSIV-ITER project. 8th International Nanotoxicology Congress (1-4 juin 2016; Boston, USA).

• Uboldi C, Orsière T, Darolles C, Aloin V, Tassistro V, George I, Malard V. Poorly soluble Co3O4P and CoCl2 exert genotoxicity in lung cells by different mechanisms. 8th International Nanotoxicology Congress (1-4 juin 2016; Boston, USA).

• George I, Hagège A, Herlin N, Vrel D, Rose J, Sanles M, Orsière T, Uboldi C, Grisolia C, Rousseau B, Malard V. Assessment of respiratory toxicity of ITER-like tungsten metal nanoparticles using an in vitro 3D human airway epithelium model. 51st Congress of the European Societies of Toxicology (13-16 septembre 2015; Porto, Portugal).

• Uboldi C, Sanles M, George I, Vrel D, Grisolia C, Rose J, Malard V, Orsière T. ITER-like tungsten nanoparticles: genotoxic potential in BEAS-2B cells. Forum annuel de la Société Française de Toxicologie Génétique (2-3 juillet 2015; Caen, France).

• George I, Hagège A, Herlin N, Vrel D, Rose J, Sanles M, Orsière T, Uboldi C, Grisolia C, Rousseau B, Malard V. Evaluation de la toxicité respiratoire de nanoparticules de tungstène ITER-like sur un modèle in vitro d’épithélium pulmonaire humain. Forum annuel de la Société Française de Toxicologie Génétique (2-3 juillet 2015; Caen, France).

• Uboldi C, Di Bucchianico S, Blosi M, Ortelli S, Coppedé F, Costa A, Migliore L. The importance of surface coatings in determining the toxic potential of nanoparticles. 11th International Conference on Environmental Mutagens (3-8 novembre 2013; Foz do Iguaçu, Brazil).

• Kinsner-Ovaskainen A, Uboldi C, Cydzik I, Simonelli F, Alloa E, Ceridono M, Gilliland D, Ponti J, Rossi F. Assessment of cytotoxicity, intracellular uptake and intestinal absorption of amorphous silica nanoparticles in the Caco-2 in vitro human intestinal barrier model. NanoSafe 2012 (13-15 novembre 2012; Grenoble, France).

• Farcal LR, Uboldi C, Mehn D, Giudetti G, Nativo P, Ponti J, Gilliland D, Rossi F and Bal-Price A. The response of an in vitro human alveolar barrier to SiO2 nanoparticles exposure in the presence or absence of THP-1 monocytes. 9th International Conference and Workshop on Biological Barriers (29 février – 3 mars 2012; Sarrebruck, Allemagne).

• Uboldi C, Giudetti G, Ponti J, Gilliland D, Rossi F. Use of fluorescent amorphous silica to study the intracellular fate of nanoparticles. 3rd NanoImpactNet Conference (14-17 février 2011; Lausanne, Suisse).

• Mittler F, Uboldi C, Delmas T, Broggi F, Boisseau P, Rossi F, Vinet F, Texier I, Ponti J, Navarro FP. Lipidots™: des nanoparticules biodégradables pour l’imagerie médicale et/ou la délivrance de médicaments. Materiaux (18-22 octobre 2010; Nantes, France).

• Freese C, Uboldi C, Gibson M, Klok HA, Unger RE and Kirkpatrick CJ. Uptake and cytotoxicity of gold nanoparticles: effects on human endothelial cells and comparison with human epithelial cells. Nanotoxicology 2010 (2-4 juin 2010; Édimbourg, Écosse).

• Freese C, Uboldi C, Gibson M, Klok HA, Unger RE and Kirkpatrick CJ. Adsorption and uptake of gold nanoparticles of different sizes, shapes and coatings in endothelial cells from different locations in the body. EuroNanoMedicine Conference (28-30 septembre 2009; Bled, Slovénie).

• Uboldi C, Barth S, Unger RE, Kirkpatrick CJ. Surface modification influences the in vitro toxicity of gold nanoparticles in human alveolar type-II cell lines. 15th Congress on Alternatives to Animal Testing (19-21 septembre 2008; Linz, Autriche).

• Uboldi C, Barth S, Unger RE and Kirkpatrick CJ. In vitro toxicity of cobalt particles on human alveolar type-II cells. 2nd International Conference on Nanotoxicology (7-10 septembre 2008; Zurich, Suisse).

• Ponti J, Colognato R, Franchini F, Gioria S, Simonelli F, Abbas K, Uboldi C, Kirkpatrick CJ, Holzwarth U and Rossi F. In vitro approach to study the internalisation of gold nanoparticles: from synthesis to cytotoxicity. 2nd International Conference on Nanotoxicology (7-10 septembre 2008; Zurich, Suisse).

• Ponti J, Colognato R, Franchini F, Gioria S, Uboldi C, Kirkpatrick CJ, Simonelli F, Abbas K, Rossi F. Uptake and cytotoxicity of gold nanoparticles in MDCK and HepG2 cell lines. NanoTech 2008 (13-15 février 2008; Tokyo, Japon).

• Hermanns I, Dubruel P, Uboldi C, Schacht E, Kirkpatrick CJ. In vitro toxicity of polyethyleneimine nanoparticles on human distal lung cells in mono- and co-culture. 14th Congress on Alternatives to Animal Testing (28-30 septembre 2007; Linz, Autriche).

• Uboldi C, Alt C, Estess P, Siegelman M, Engelhardt B. SJL/L-Selectin Deficient Mice Develop Experimental Autoimmune Encephalomyelitis. Forum annuel de la Société Suisse d’Allergologie et Immunologie (30-31 mars 2006; Zurich, Suisse).

• Uboldi C, Estess P, Siegelman M, Engelhardt B. SJL/L-Selectin Deficient Mice Develop Experimental Autoimmune Encephalomyelitis. Forum annuel de la Société Suisse d’Allergologie et Immunologie (3-4 mars 2005; Berne, Suisse).

National and international research projects

06/2018-onwards : TILT (Toxicologie transverse aux case-studies), in the frame of LabEx SERENADE (Safer Ecodesign Research and Education applied to NAnomaterial Development). www.labex-serenade.fr
Development of an in vitro mutagenicity test applicable to nanoparticles.

10/2014-10/2016 : PASSIV-ITER, funded by A*MIDEX (Aix Marseille Initiatives d’Excellence). Coordinator: Dr. Christian Grisolia (CEA Cadarache, France).
Passivation strategies on submicrometric tritiated and non tritiated tungsten particles based on their physico-chemical characterisation and on the evaluation of their cytogenotoxic potential.

02/2013-09/2014 : SanoWork (Safe Nano Worker Exposure Scenarios), EU FP7 project (projet no. 280716). Coordinator: Dr. Anna Costa (Faenza, Italy).
Developpement and identification of a safe occupational exposure scenario by exposure assessment in real conditions and at all stages of nanomaterials production, use and disposal. Safe-by-design concept.

10/2009-09/2012 : NanoReTox (The reactivity and toxicity of engineered nanoparticles: risks to the environment and human health), EU FP7 project (projet no. 214478). Coordinator: Pr. Eugenia Valsami-Jones (University of Birmingham, Birmingham, UK).
Study of the in vitro absorption and reactivity of nanoparticles and their possible toxicity mechanisms. Focus on the cytogenotoxic and carcinogenic potential of metallic nanoparticles.

10/2009-09/2012 : NanoTher (Integration of novel NANOparticle based technology for THERapeutics and diagnosis of different types of cancer), EU FP7 project (projet no. CP-IP213631-2NANOTHER).
Coordinator of sub-project ”SP2: Toxicology and Biocompatibility of nanoparticles”.
Development and characterisation of novel nanoparticle systems (polymeric nanocarriers) that will be used as therapeutic agents or diagnosis tools for breast cancer, colorectal cancer & bone metastasis. Selection of the best nano-supports taking into account the toxicity, biocompatibility, efficiency and biodistribution of nanomaterials.

09/2006-09/2009 : CellNanoTox (Cellular Interaction and Toxicology with Engineered Nanoparticles), EU FP7 project (projet no. NMP4-CT-2006-032731). Coordinator of workpackage ”WP4: Mechanisms of interaction, uptake, recycling of NPs with in vitro cellular model systems of lung, intestine, kidney and the immune system and characterization of transport through epithelial borders”.
Development of multidisciplinary strategies, tests and indicators of the toxicological profile of nanoparticles. Identification of correlations between the physico-chemical characteristics of nanoparticles and their toxic potential on various organs of the human body.