{"id":9544,"date":"2025-11-19T15:50:04","date_gmt":"2025-11-19T14:50:04","guid":{"rendered":"https:\/\/www.imbe.fr\/?post_type=tribe_events&#038;p=9544"},"modified":"2025-11-19T16:23:54","modified_gmt":"2025-11-19T15:23:54","slug":"these-de-achard-baccati-clementine-valorisation-ethnopharmacologique-de-cinq-especes-vegetales-provencales-du-parc-naturel-regional-du-luberon","status":"publish","type":"tribe_events","link":"https:\/\/www.imbe.fr\/en\/evenement\/these-de-achard-baccati-clementine-valorisation-ethnopharmacologique-de-cinq-especes-vegetales-provencales-du-parc-naturel-regional-du-luberon\/","title":{"rendered":"Thesis by ACHARD-BACCATI Cl\u00e9mentine \u201cEthnopharmacological valuation of five Proven\u00e7al plant species from the Luberon Regional Nature Park\u201d.\u201d"},"content":{"rendered":"<p><strong>Mada<\/strong><strong>me <a href=\"https:\/\/www.imbe.fr\/en\/annuaire\/clementine-baccati\/\">ACHARD-BACCATI Cl\u00e9mentine<\/a>,<\/strong> doctoral student at IMBE, team<a href=\"https:\/\/www.imbe.fr\/en\/recherche\/equipes-de-recherche\/ecosom-ecologie-fonctionnelle-des-systemes-socioecologiques-aux-molecules\/\"> Functional ecology: from socio-ecological systems to molecules<\/a>, <strong>will publicly defend his thesis on Friday 12 December 2025 at 9am in the Thesis Room, Faculty of Pharmacy, La Timone.<\/strong><\/p>\n<p><strong>In front of a jury made up of :<\/strong><\/p>\n<ul>\n<li><strong>Anne Gauvin-Bialecki,<\/strong> Rapporteur, Professor, University of La R\u00e9union<\/li>\n<li><strong>Fran\u00e7ois Chassagne, <\/strong>Rapporteur, Research Fellow, IRD Noum\u00e9a<\/li>\n<li><strong>Dominique Laurain-Mattar, <\/strong>Chair of the jury, University Professor, University of Lorraine<\/li>\n<li><strong>G\u00e9rald Culioli, <\/strong>Examiner, University Professor, Avignon University<\/li>\n<li><strong>B\u00e9atrice BAGHDIKIAN<\/strong>, Director of thesis, Senior Lecturer HDR, Aix-Marseille University<\/li>\n<li><strong>Elnur GARAYEV<\/strong>, PhD thesis co-director, Senior Lecturer, Aix-Marseille University<\/li>\n<li><strong>Sylvie MOREL<\/strong>, Guest lecturer, University of Montpellier<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Summary of work:<\/strong><\/p>\n<p>This thesis proposes an ethnopharmacological approach to the development of Proven\u00e7al medicinal plants from the Parc Naturel R\u00e9gional du Luberon. This approach is based on the ethnobotanical inventories carried out by Pierre Lieutaghi and Magali Amir in order to select five medicinal plant species used in traditional Proven\u00e7al medicine for cutaneous purposes: <em>Helichrysum stoechas, Pilosella officinarum, Plantago sempervirens, Rubus ulmifolius<\/em> and<em> Satureja montana<\/em>.<\/p>\n<p>Plant drugs from each selected species were extracted ultrasonically with a hydro-ethanol mixture, and the resulting extracts were fractionated by liquid\/liquid extraction.<\/p>\n<p>The extracts and fractions were subjected to biological screening to assess activities related to traditional uses: antioxidant (DPPH\/ABTS in microplate and on-line UHPLC-DAD-DPPH\/ABTS-MS\/MS coupling), anti-inflammatory (NO inhibition), antimicrobial (inhibition diameters and MICs on skin microbiota strains) and healing (scratch-test on keratinocytes).<\/p>\n<p>At the same time, the chemical composition was studied using UHPLC-HRMS\/MS and GC-MS analyses. Dereplication and the use of molecular networks were used to describe the chemical diversity of the extracts and fractions, and to highlight the chemical families contributing to the biological activities assessed.<\/p>\n<p>On-line UHPLC-DAD-DPPH\/ABTS-MS\/MS coupling was used to accurately determine the compounds responsible for the antioxidant activity. Given its high antioxidant potential and favourable natural abundance, the species <em>Rubus ulmifolius<\/em> has been selected for industrial development. Sanguiin-H6, identified as the main contributor to the antioxidant activity of <em>R. ulmifolius<\/em>, was isolated by preparative HPLC and its structure confirmed by NMR. The development of a specific HPLC-UV assay method and the implementation of a design of experiments made it possible to optimise the extraction conditions in order to increase the concentration of sanguiin-H6 in hydro-glycerol extracts.<\/p>\n<p>Overall, the experimental results support local ethnopharmacological knowledge of skin uses, with the anti-oxidant, anti-inflammatory and anti-microbial profiles of the species studied.<\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Madame ACHARD-BACCATI Cl\u00e9mentine, doctorante \u00e0 l\u2019IMBE, \u00e9quipe Ecologie fonctionnelle : des syst\u00e8mes socio\u00e9cologiques aux mol\u00e9cules, soutiendra publiquement ses travaux de th\u00e8se le vendredi 12 d\u00e9cembre 2025, \u00e0 9h dans la [&hellip;]<\/p>\n","protected":false},"author":300,"featured_media":0,"template":"","meta":{"_acf_changed":false,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[30],"class_list":["post-9544","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-soutenance","cat_soutenance"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/tribe_events\/9544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/users\/300"}],"version-history":[{"count":2,"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/tribe_events\/9544\/revisions"}],"predecessor-version":[{"id":9549,"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/tribe_events\/9544\/revisions\/9549"}],"wp:attachment":[{"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/media?parent=9544"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/tags?post=9544"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/www.imbe.fr\/en\/wp-json\/wp\/v2\/tribe_events_cat?post=9544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}