{"id":9544,"global_id":"www.imbe.fr\/fr?id=9544","global_id_lineage":["www.imbe.fr\/fr?id=9544"],"author":"300","status":"publish","date":"2025-11-19 15:50:04","date_utc":"2025-11-19 14:50:04","modified":"2025-11-19 16:23:54","modified_utc":"2025-11-19 15:23:54","url":"https:\/\/www.imbe.fr\/fr\/evenement\/these-de-achard-baccati-clementine-valorisation-ethnopharmacologique-de-cinq-especes-vegetales-provencales-du-parc-naturel-regional-du-luberon\/","rest_url":"https:\/\/www.imbe.fr\/fr\/wp-json\/tribe\/events\/v1\/events\/9544","title":"Th\u00e8se de ACHARD-BACCATI Cl\u00e9mentine &#8220;Valorisation ethnopharmacologique de cinq esp\u00e8ces v\u00e9g\u00e9tales Proven\u00e7ales du Parc Naturel R\u00e9gional du Luberon&#8221;","description":"<p><strong>Mada<\/strong><strong>me <a href=\"https:\/\/www.imbe.fr\/fr\/annuaire\/clementine-baccati\/\">ACHARD-BACCATI Cl\u00e9mentine<\/a>,<\/strong> doctorante \u00e0 l\u2019IMBE, \u00e9quipe<a href=\"https:\/\/www.imbe.fr\/fr\/recherche\/equipes-de-recherche\/ecosom-ecologie-fonctionnelle-des-systemes-socioecologiques-aux-molecules\/\"> Ecologie fonctionnelle : des syst\u00e8mes socio\u00e9cologiques aux mol\u00e9cules<\/a>, <strong>soutiendra publiquement ses travaux de th\u00e8se le vendredi 12 d\u00e9cembre 2025, \u00e0 9h dans la salle des th\u00e8ses, Facult\u00e9 de pharmacie, La Timone.<\/strong><\/p>\n<p><strong>Devant le jury compos\u00e9 de :<\/strong><\/p>\n<ul>\n<li><strong>Anne Gauvin-Bialecki,<\/strong> Rapporteure, Professeure des Universit\u00e9s, Universit\u00e9 de La R\u00e9union<\/li>\n<li><strong>Fran\u00e7ois Chassagne, <\/strong>Rapporteur, Charg\u00e9 de Recherches, IRD Noum\u00e9a<\/li>\n<li><strong>Dominique Laurain-Mattar, <\/strong>Pr\u00e9sidente du jury, Professeure des Universit\u00e9s, Universit\u00e9 de Lorraine<\/li>\n<li><strong>G\u00e9rald Culioli, <\/strong>Examinateur, Professeur des Universit\u00e9s, Avignon Universit\u00e9<\/li>\n<li><strong>B\u00e9atrice BAGHDIKIAN<\/strong>, Directrice de th\u00e8se, Ma\u00eetre de Conf\u00e9rences HDR, Aix-Marseille Universit\u00e9<\/li>\n<li><strong>Elnur GARAYEV<\/strong>, Co-directeur de th\u00e8se, Ma\u00eetre de Conf\u00e9rences, Aix-Marseille Universit\u00e9<\/li>\n<li><strong>Sylvie MOREL<\/strong>, Membre invit\u00e9e, Ma\u00eetre de Conf\u00e9rences, Universit\u00e9 de Montpellier<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>R\u00e9sum\u00e9 des travaux :<\/strong><\/p>\n<p>Cette th\u00e8se propose une d\u00e9marche ethnopharmacologique pour la valorisation de plantes m\u00e9dicinales Proven\u00e7ales issues du Parc Naturel R\u00e9gional du Luberon. Cette approche s\u2019appuie sur les inventaires ethnobotaniques de Pierre Lieutaghi et Magali Amir afin de s\u00e9lectionner cinq esp\u00e8ces de plantes m\u00e9dicinales utilis\u00e9es en m\u00e9decine traditionnelle Proven\u00e7ale pour des usages cutan\u00e9s : <em>Helichrysum stoechas, Pilosella officinarum, Plantago sempervirens, Rubus ulmifolius<\/em> et<em> Satureja montana<\/em>.<\/p>\n<p>Les drogues v\u00e9g\u00e9tales de chaque esp\u00e8ce s\u00e9lectionn\u00e9e ont \u00e9t\u00e9 extraites aux ultrasons avec un m\u00e9lange hydro-\u00e9thanolique, les extraits r\u00e9sultant ont \u00e9t\u00e9 fractionn\u00e9s par extraction liquide\/liquide.<\/p>\n<p>Les extraits et fractions ont fait l\u2019objet d\u2019un criblage biologique pour \u00e9valuer des activit\u00e9s en lien avec les usages traditionnels : anti-oxydante (DPPH\/ABTS en microplaque et couplage en ligne UHPLC-DAD-DPPH\/ABTS-MS\/MS), anti-inflammatoire (inhibition du NO), anti-microbienne (diam\u00e8tres d\u2019inhibition et CMI sur souches du microbiote cutan\u00e9) et cicatrisante (scratch-test sur k\u00e9ratinocytes).<\/p>\n<p>En parall\u00e8le, la composition chimique a \u00e9t\u00e9 \u00e9tudi\u00e9e par des analyses UHPLC-HRMS\/MS et GC-MS. La d\u00e9r\u00e9plication et l\u2019emploi des r\u00e9seaux mol\u00e9culaires ont permis de d\u00e9crire la diversit\u00e9 chimique des extraits et fractions, et de mettre en \u00e9vidence des familles chimiques contribuant aux activit\u00e9s biologiques \u00e9valu\u00e9es.<\/p>\n<p>Le couplage On-Line UHPLC-DAD-DPPH\/ABTS-MS\/MS a permis de d\u00e9terminer avec pr\u00e9cision les compos\u00e9s responsables de l\u2019activit\u00e9 anti-oxydante. Compte tenu d\u2019un fort potentiel anti-oxydant et d\u2019une abondance naturelle favorable, l\u2019esp\u00e8ce <em>Rubus ulmifolius<\/em> a \u00e9t\u00e9 retenue pour une valorisation industrielle. La sanguiine-H6, identifi\u00e9e comme principal contributeur \u00e0 l\u2019activit\u00e9 anti-oxydante de <em>R. ulmifolius<\/em>, a \u00e9t\u00e9 isol\u00e9e par HPLC pr\u00e9parative et sa structure a \u00e9t\u00e9 confirm\u00e9e par RMN. Le d\u00e9veloppement d\u2019une m\u00e9thode de dosage sp\u00e9cifique en HPLC-UV et la mise en \u0153uvre d\u2019un plan d\u2019exp\u00e9riences ont permis d\u2019optimiser les conditions d\u2019extraction pour majorer la concentration en sanguiine-H6 dans des extraits hydro-glyc\u00e9rin\u00e9s.<\/p>\n<p>Dans l\u2019ensemble, les r\u00e9sultats exp\u00e9rimentaux soutiennent les savoirs ethnopharmacologiques locaux relatifs aux usages cutan\u00e9s, avec des profils anti-oxydants, anti-inflammatoires et anti-microbiens des esp\u00e8ces \u00e9tudi\u00e9es.<\/p>\n<p>&nbsp;<\/p>","excerpt":"","slug":"these-de-achard-baccati-clementine-valorisation-ethnopharmacologique-de-cinq-especes-vegetales-provencales-du-parc-naturel-regional-du-luberon","image":false,"all_day":false,"start_date":"2025-12-12 09:00:00","start_date_details":{"year":"2025","month":"12","day":"12","hour":"09","minutes":"00","seconds":"00"},"end_date":"2025-12-12 11:00:00","end_date_details":{"year":"2025","month":"12","day":"12","hour":"11","minutes":"00","seconds":"00"},"utc_start_date":"2025-12-12 08:00:00","utc_start_date_details":{"year":"2025","month":"12","day":"12","hour":"08","minutes":"00","seconds":"00"},"utc_end_date":"2025-12-12 10:00:00","utc_end_date_details":{"year":"2025","month":"12","day":"12","hour":"10","minutes":"00","seconds":"00"},"timezone":"Europe\/Paris","timezone_abbr":"CET","cost":"","cost_details":{"currency_symbol":"\u20ac","currency_code":"EUR","currency_position":"prefix","values":[]},"website":"","show_map":true,"show_map_link":true,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Soutenance","slug":"soutenance","term_group":0,"term_taxonomy_id":30,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":19,"filter":"raw","id":30,"urls":{"self":"https:\/\/www.imbe.fr\/fr\/wp-json\/tribe\/events\/v1\/categories\/30","collection":"https:\/\/www.imbe.fr\/fr\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":{"id":9518,"author":"300","status":"publish","date":"2025-11-10 09:31:32","date_utc":"2025-11-10 08:31:32","modified":"2025-11-10 09:31:32","modified_utc":"2025-11-10 08:31:32","url":"https:\/\/www.imbe.fr\/fr\/lieu\/salle-des-heses-faculte-de-pharmacie\/","venue":"Salle des h\u00e8ses &#8211; Facult\u00e9 de Pharmacie","slug":"salle-des-heses-faculte-de-pharmacie","address":"Campus Timone. 27 boulevard Jean Moulin","city":"Marseille CEDEX 05","zip":"13385","json_ld":{"@type":"Place","name":"Salle des h\u00e8ses &#8211; Facult\u00e9 de Pharmacie","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"Campus Timone. 27 boulevard Jean Moulin","addressLocality":"Marseille CEDEX 05","postalCode":"13385"},"telephone":"","sameAs":""},"show_map":true,"show_map_link":true,"global_id":"www.imbe.fr\/fr?id=9518","global_id_lineage":["www.imbe.fr\/fr?id=9518"]},"organizer":[],"custom_fields":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Th\u00e8se de ACHARD-BACCATI Cl\u00e9mentine &#8220;Valorisation ethnopharmacologique de cinq esp\u00e8ces v\u00e9g\u00e9tales Proven\u00e7ales du Parc Naturel R\u00e9gional du Luberon&#8221;","description":"&lt;p&gt;Madame ACHARD-BACCATI Cl\u00e9mentine, doctorante \u00e0 l\u2019IMBE, \u00e9quipe Ecologie fonctionnelle : des syst\u00e8mes socio\u00e9cologiques aux mol\u00e9cules, soutiendra publiquement ses travaux de th\u00e8se le vendredi 12 d\u00e9cembre 2025, \u00e0 9h dans la [&hellip;]&lt;\/p&gt;\\n","url":"https:\/\/www.imbe.fr\/fr\/evenement\/these-de-achard-baccati-clementine-valorisation-ethnopharmacologique-de-cinq-especes-vegetales-provencales-du-parc-naturel-regional-du-luberon\/","eventAttendanceMode":"https:\/\/schema.org\/OfflineEventAttendanceMode","eventStatus":"https:\/\/schema.org\/EventScheduled","startDate":"2025-12-12T09:00:00+01:00","endDate":"2025-12-12T11:00:00+01:00","location":{"@type":"Place","name":"Salle des h\u00e8ses &#8211; Facult\u00e9 de Pharmacie","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"Campus Timone. 27 boulevard Jean Moulin","addressLocality":"Marseille CEDEX 05","postalCode":"13385"},"telephone":"","sameAs":""},"performer":"Organization"}}