A chemist in the middle of the sea

Young scientist passionate about multi-disciplinary researches, I am carrying out a PhD combining chemistry, the valorization of marine natural products in drug-discovery and marine chemical ecology. My PhD is dedicated to the chemical investigations and biological valorization of sponge metabolites naturally released in seawater. I am particularly motivated by the valorization of natural products to fight multi-drugs resistant bacteria (MDR) and re-emerging diseases, such as flavivirus.
Beside my PhD work, I also enjoy participating in outreach activities sensitizing the young generation to better knowledge of the marine world.

PhD subject

In the context of the ANR SESAM (coord. Charlotte Simmler), my PhD subject is untitled: Capture of sponge exo-metabolites, chemical characterization and evaluation of their anti-microbials properties. I am supervised by Charlotte Simmler and Thierry Pérez.

Key words

Exo-metabolites, marine sponges, marine natural products, chemical ecology

Professional Experiences

Since Nov. 2020: PhD student in marine natural products
Subject: “Capture of sponge exo-metabolites, chemical characterization and evaluation of their anti-microbials properties”
Supervisors: Thierry Pérez and Charlotte Simmler. 80 Primes CNRS MITI fellowship.

2020: Research internship
Subject: “Optimizing the capture of Aplysina cavernicola exo-metabolites by solid phase adsorption”
Supervisors: Charlotte Simmler, Stéphane Greff and Thierry Pérez
Laboratory: Mediterranean Institute of Terrestrial and Marine Biodiversity and Ecology (IMBE)

2018 – 2019: European Volunteering Service
In charge of the Eko-Patrola program: Scientific mediation and non-formal education for local children.
Organization: Udruga Argonauta. Island of Murter, Croatia.
https://argonauta.hr/en/

2018: Engineer internship
Subject: “Development of biocompatible hydrogel fibres using wet-spinning technique and application in 3D printing”
Supervisors: Anaïs Chalard and Pierre Joseph
Laboratory: Laboratory for Analysis and Architecture of Systems (LAAS-CNRS).
Research group: Micro-Nanofluidics for Life science and Environment (MILE). Toulouse, France.

Education

2014 – 2020: Engineer in Chemistry – Master’s degree in Chemistry
Ecole Supérieure de Chimie Organique et Minérale (ESCOM). Compiègne, France.

Thanks

I would like to deeply thanks all the advisors and teachers who shared and transmitted me theirs passions for sciences and researches.

Publications

2023: In situ Capture and Real Time Enrichment of Marine Chemical Diversity , Mauduit M., Derrien M., Grenier M., Molinari S., Greff S., Chevaldonné P., Pérez T., and Simmler C., ACS Central Science https://doi.org/10.1021/acscentsci.3c00661

2022: Diving into the Molecular Diversity of Aplysina cavernicola’s Exometabolites: Contribution of Bromo-Spiroisoxazoline Alkaloids , Mauduit M., Greff S., Herbette G., Naubron J-V., Chentouf S., Huy Ngo T., Nam J-W., Molinari S., Mabrouki F., Garayev E., Baghdikian B., Pérez T., and Simmler C., ACS Omega https://doi.org/10.1021/acsomega.2c05415

ORAL COMMUNICATION
2023 : 31st International Symposium on the Chemistry of Natural Products & 11th International Congress on Biodiversity (ISCNP31 & ICOB11). Naples, Italy.
“Accessing the hidden treasure of brominated exometabolites released by two Mediterranean sponges” M. Mauduit, S. Greff, P. Chevaldonné, T. Pérez, C. Simmler

2021: Journées du GDR MediaTEC (Ecologie Chimique). Toulouse, France.
“Access the diversity of molecules naturally released by sponges : Exo-metabolites, Catch them (all)!” M. Mauduit, S. Greff, T. Pérez, C. Simmler

POSTERS
2022: 11th International Sponge Symposium . Leiden, Pays-Bas.
“Diving into the chemistry of sponge exo-metabolomes: contribution of brominated specialized metabolites” M. Mauduit, S. Greff, T. Pérez, C. Simmler

2022: METABIODIVEX: Molecular Exploration of Biodiversity: new challenges, new strategies . Aussois, France.
“Diving into the chemistry of sponge exo-metabolomes: contribution of brominated specialized metabolites” M. Mauduit, S. Greff, T. Pérez, C. Simmler
Best poster award

2021: XII European Conference on Marine Natural Products (ECMNP). Galway, Ireland (on-line).
“Exploring the diversity of brominated alkaloids naturally released by the sponge Aplysina cavernicola” M. Mauduit, S. Greff, T. Pérez, C. Simmler

Thematic Schools

2022: First European School of Metabolomics. International, Moustiers-Sainte-Marie, France.

2022: Global Young Scientits Summit. International, online.

Publications - Others

2022: “LC-MS Based Phytochemical Profiling towards the Identification of Antioxidant Markers in Some Endemic Aloe Species from Mascarene Islands” C. Breaud, L. Lallemand, G. Mares, F. Mabrouki, M. Bertolotti, C. Simmler, S. Greff, M. Mauduit, G. Herbette, E. Garayev, C. Lavergne, M. Cesari, S-S Bun-Llopet, B. Baghdikian, E. Garayev, Antioxidants https://doi.org/10.3390/antiox12010050

2020: “3D printing of a biocompatible low molecular weight supramolecular hydrogel by dimethylsulfoxide water solvent exchange”, A. Chalard, M. Mauduit, S. Souleille, P. Joseph, L. Malaquin, J. Fitremann, Additive Manufacturing https://doi.org/10.1016/j.addma.2020.101162