National and international research projects

06/2018-onwards : TILT (Toxicologie transverse aux case-studies), in the frame of LabEx SERENADE (Safer Ecodesign Research and Education applied to NAnomaterial Development). www.labex-serenade.fr
Development of an in vitro mutagenicity test applicable to nanoparticles.

10/2014-10/2016 : PASSIV-ITER, funded by A*MIDEX (Aix Marseille Initiatives d’Excellence). Coordinator: Dr. Christian Grisolia (CEA Cadarache, France).
Passivation strategies on submicrometric tritiated and non tritiated tungsten particles based on their physico-chemical characterisation and on the evaluation of their cytogenotoxic potential.

02/2013-09/2014 : SanoWork (Safe Nano Worker Exposure Scenarios), EU FP7 project (projet no. 280716). Coordinator: Dr. Anna Costa (Faenza, Italy).
Developpement and identification of a safe occupational exposure scenario by exposure assessment in real conditions and at all stages of nanomaterials production, use and disposal. Safe-by-design concept.

10/2009-09/2012 : NanoReTox (The reactivity and toxicity of engineered nanoparticles: risks to the environment and human health), EU FP7 project (projet no. 214478). Coordinator: Pr. Eugenia Valsami-Jones (University of Birmingham, Birmingham, UK).
Study of the in vitro absorption and reactivity of nanoparticles and their possible toxicity mechanisms. Focus on the cytogenotoxic and carcinogenic potential of metallic nanoparticles.

10/2009-09/2012 : NanoTher (Integration of novel NANOparticle based technology for THERapeutics and diagnosis of different types of cancer), EU FP7 project (projet no. CP-IP213631-2NANOTHER).
Coordinator of sub-project ”SP2: Toxicology and Biocompatibility of nanoparticles”.
Development and characterisation of novel nanoparticle systems (polymeric nanocarriers) that will be used as therapeutic agents or diagnosis tools for breast cancer, colorectal cancer & bone metastasis. Selection of the best nano-supports taking into account the toxicity, biocompatibility, efficiency and biodistribution of nanomaterials.

09/2006-09/2009 : CellNanoTox (Cellular Interaction and Toxicology with Engineered Nanoparticles), EU FP7 project (projet no. NMP4-CT-2006-032731). Coordinator of workpackage ”WP4: Mechanisms of interaction, uptake, recycling of NPs with in vitro cellular model systems of lung, intestine, kidney and the immune system and characterization of transport through epithelial borders”.
Development of multidisciplinary strategies, tests and indicators of the toxicological profile of nanoparticles. Identification of correlations between the physico-chemical characteristics of nanoparticles and their toxic potential on various organs of the human body.