Original research papers published in peer-reviewed journals

George I*, Uboldi C*, Bernard E, Sobrido MS, Dine S, Hagège A, Vrel D, Herlin N, Rose J, Orsière T, Grisolia C, Rousseau B, Malard V. Toxicological Assessment of ITER-Like Tungsten Nanoparticles Using an In Vitro 3D Human Airway Epithelium Model. Nanomaterials, 2019; 9(10). doi: 10.3390/nano9101374. * equally contributed

Uboldi C, Sanles Sobrido M, Bernard E, Tassistro V, Herlin-Boime N, Vrel D, Garcia-Argote S, Roche S, Magdinier F, Dinescu G, Malard V, Lebaron-Jacobs L, Rose J, Rousseau B, Delaporte P, Grisolia C, Orsière T. In vitro analysis of the effects of ITER-like tungsten nanoparticles : cytotoxicity and epigenotoxicity in BEAS-2B cells. Nanomaterials, 2019; 9(9):1233. doi: 10.3390/nano9091233.

Bernard E, Jambon F, Georges I, Sanles Sobrido M, Rose J, Herlin-Boime N, Miserque F, Beaunier P, Vrel D, Dine S, Hodille E, Chêne J, Garcia-Argote S, Pieters G, Peillon S, Gensdarmes F, Dinescu G, Acsente T, Uboldi C, Orsiere T, Malardv, Rousseau B, Dine G, Delaporte P, Grisoliac. Design of model tokamak particles for future toxicity studies: morphology and physical characterization. Fusion Engineering And Design, 2019; 145:60-65. doi: 10.1016/J.Fusengdes.2019.05.037.

Grisolia C, Gensdarmes F, Peillon S, Dougniaux G, Bernard E, Autricque A, Pieters G, Rousseau B, Feuillastre S, Garcia-Argote S, Carvalho S, Malard V, George I, Lebaron-Jacobs L, Orsière T, Uboldi C, Rose J, Senles M, Lambertin D, Vrel D, Decanis C, Liger K. Current investigations on tritiated dust and their impact on tokamak safety. Nucl. Fusion, 2019; 59:086061. https://doi.org/10.1088/1741-4326/ab1a76.

Malard V, Bresson C, Uboldi C, Delangle P, Van der Meeren A, Lemaire D, Darolles C, Orsière T, Ortega R, Berthomieu C. Toxicity mechanisms of cobalt oxide particles (Co3O4P) on human lung cells: impact of solubilization. BIO Web of Conferences, 2019; 14:05010.

Stoccoro A, Di Bucchianico S, Coppedè F, Ponti J, Uboldi C, Blosi M, Delpivo C, Ortelli S, Costa AL, Migliore L. Multiple endpoints to evaluate pristine and remediated titanium dioxide nanoparticles genotoxicity in lung epithelial A549 cells. Toxicology letters, 2017; 276:49-61.

Stoccoro A, Di Bucchianico S, Uboldi C, Coppedè F, Ponti J, Placidi C, Blosi M, Ortelli S, Costa AL and Migliore L. A panel of in vitro tests to evaluate genotoxic and morphological neoplastic transformation potential on Balb/3T3 cells by pristine and remediated titania and zirconia nanoparticles. Mutagenesis, 2016; 31(5):511-29. doi: 10.1093/mutage/gew015.

Choukourov A, Gordeev I, Ponti J, Uboldi C, Melnichuk I, Vaidulych M, Kousal J, Nikitin D, Hanyková L, Krakovský I, Slavínská D and Biederman H. Microphase-Separated PE/PEO Thin Films Prepared by Plasma-Assisted Vapor Phase Deposition. ACS Appl Mater Interfaces, 2016; 8(12):8201-12. doi: 10.1021/acsami.5b12382.

Uboldi C, Urbàn P, Ponti J, Bayak E, Valsami-Jones E, Gilliland D and Rossi F. Rutile titanium dioxide nanoparticles induce cytotoxicity and morphological transformation in Balb/3T3 cells. Toxicol in vitro, 2016; 31:137-45; doi: 10.1016/j.tiv.2015.11.005.

Uboldi C, Orsière T, Darolles C, Aloin V, Tassistro V, George I and Malard V. Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways. Part Fibre Toxicol, 2016; 13(1):5. doi: 10.1186/s12989-016-0118-8.

Migliore L, Uboldi C, Di Bucchianico S, Coppede F. Nanomaterials and neurodegeneration. Environ Molecular Mutagen, 2015; 56 (2):149-170. doi: 10.1002/em.21931.

Locatelli E, Naddaka M, Uboldi C, Loudos G, Fragogeorgi E, Molinari V, Pucci A, Tsotakos T, Psimadas D, Ponti J and Comes Franchini M. Targeted delivery of silver nanoparticles and Alisertib. In vitro and in vivo synergistic effect against glioblastoma. Nanomedicine, 2014; 9(6):839–849. doi: 10.2217/nnm.14.1.

Di Bucchianico S, Fabbrizi MR, Cirillo S, Uboldi C, Gilliland D, Valsami-Jones E and Migliore L. Aneuploidogenic effects and DNA oxidation induced in vitro by differently sized gold nanoparticles. Int J Nanomedicine, 2014; 9:2191–2204. doi: 10.2147/IJN.S58397.

Goñi-de-Cerio F, Mariani V, Cohen D, Madi L, Thevenot J, Oliveira H, Uboldi C, Giudetti G, Coradeghini R, Garanger E, Rossi F, Portugal-Cohen M, Oron M, Korenstein R, Lecommandoux S, Ponti J, Suárez-Merino B and Heredia P. Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity testing. J Nanopart Res, 2013; 15:2036. doi:10.1007/s11051-013-2036-0.

Horev-Azaria L, Korenstein R, Beno D, Bonacchi D, Baldi G, Golla-Schindler U, Sommer D, Kirkpatrick CJ, Unger RE, Uboldi C, Landsiedel R, Kolle S, Maimon O, Romano R, Villiers C, Marche P, Ponti J and Rossi F. Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data. Part Fibre Toxicol, 2013; 10:32. doi: 10.1186/1743-8977-10-32.

Pucci A, Locatelli E, Ponti J, Uboldi C, Molinari V and Comes Franchini M. Click Chemistry on the surface of PLGA-b-PEG polymeric nanoparticles: a novel targetable fluorescent imaging nanocarrier. J Nanopart Res, 2013; 15:1818. doi: 10.1007/s11051-013-1818-8.

Gianoncelli A, Marmorato P, Ponti J, Pascolo L, Kaulich B, Uboldi C, Rossi F, Makovec D, Kiskinova M and Ceccone G. Interaction Q2 of magnetic nanoparticles with U87MG cells studied by synchrotron radiation X-ray fluorescence techniques. X-Ray Spectrometry, 2013; 42(4):316-320. doi: 10.1002/xrs.2475.

De Angelis I, Barone F, Zijno A, Bizzarri L, Russo MT, Pozzi R, Franchini F, Giudetti G, Uboldi C, Ponti J, Rossi F and De Berardis B. Comparative study of toxicological effects induced by ZnO and TiO2 nanoparticles on human colon carcinoma cells. Nanotoxicology, 2013; 7(8):1361-1372. doi: 10.3109/17435390.2012.741724.

Freese C, Uboldi C, Gibson M, Klok HA, Unger RE and Kirkpatrick CJ. Uptake and cytotoxicity of gold nanoparticles: Effects on human endothelial cells and comparison with human epithelial cells. Part Fibre Toxicol, 2012; 9:23. doi: 10.1186/1743-8977-9-23.

Farcal LR, Uboldi C, Mehn D, Giudetti G, Nativo P, Ponti J, Gilliland D, Rossi F and Bal-Price A. Mechanisms of toxicity induced by SiO2 nanoparticles of in vitro human alveolar barrier: effects on cytokine production, oxidative stress induction, surfactant proteins A mRNA expression and nanoparticles uptake. Nanotoxicology, 2012; 7:1095-110. doi: 10.3109/17435390.2012.710658.

Uboldi C, Giudetti G, Broggi F, Gilliland D, Ponti J and Rossi F. Amorphous silica nanoparticles do not induce cytotoxicity, carcinogenicity nor genotoxicity in Balb/3T3 mouse fibroblasts. Mutat Res: Genet Toxicol Environ Mutagen, 2012; 745:11-20. doi: 10.1016/j.mrgentox.2011.10.010.

Horev-Azaria L, Kirkpatrick CJ, Korenstein R, Marche PN, Maimon O, Ponti J, Romano R, Rossi F, Golla-Schindler U, Sommer D, Uboldi C, Unger RE and Villiers C. Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data. Toxicol Sci, 2011; 122(2):489-501. doi: 10.1093/toxsci/kfr124.

Mittler F, Uboldi C, Delmas T, Broggi F, Boisseau P, Rossi F, Vinet F, Texier I, Ponti J, Navarro FP. Lipidots™: des nanoparticules biodégradables pour l’imagerie médicale et/ou la délivrance de médicaments. Materiaux 2010.

Ponti J, Colognato R, Franchini F, Gioria S, Simonelli F, Abbas K, Uboldi C, Kirkpatrick CJ, Holzwarth U and Rossi F. A quantitative in vitro approach to study the intracellular fate of gold nanoparticles: from synthesis to cytotoxicity. Nanotoxicology, 2009; 3(4):296–306. doi: 10.3109/17435390903056384.

Uboldi C, Bonacchi D, Lorenzi G, Hermanns MI, Pohl C, Baldi G, Unger RE and Kirkpatrick CJ. Gold nanoparticles induce in vitro cytotoxicity in the alveolar type-II cell lines A549 and NCIH441. Part Fibre Toxicol, 2009, 6:18. doi: 10.1186/1743-8977-6-18.

Hermanns MI, Kasper J, Dubruel P, Pohl C, Uboldi C, Vermeersch V, Fuchs S, Unger RE and Kirkpatrick CJ. An impaired alveolar-capillary barrier in vitro: effect of proinflammatory cytokines and consequences on nanocarrier interaction. J R Soc Interface, 2010; 7(Suppl1):S41-54. doi: 10.1098/rsif.2009.0288.focus.

Pohl C, Papritz M, Moisch M, Wübbecke C, Hermanns MI, Uboldi C, Dei-Anang J, Mayer E, Kirkpatrick CJ and Kehe K. Acute morphological and toxicological effects in a human bronchial co-culture model after Sulphur Mustard exposure. Toxicol Sci, 2009; 112(2):482-9. doi: 10.1093/toxsci/kfp211.

Pohl C, Hermanns MI, Uboldi C, Bock M, Fuchs S, Dei-Anang J, Mayer E, Kehe K, Kummer W and Kirkpatrick CJ. Barrier functions and paracellular integrity in human cell culture models of the proximal respiratory unit. Eur J Pharm Biopharm, 2009; 72(2):339-349. doi: 10.1016/j.ejpb.2008.07.012.

Uboldi C, Doering A, Alt C, Estess P, Siegelman M and Engelhardt B. L-Selectin-deficient SJL mice are not resistant to experimental autoimmune encephalomyelitis. Eur J Immunol, 2008; 38:2156-2167. doi: 10.1002/eji.200838209.

Abstracts published in peer-reviewed journals

George I, Hagège A, Herlin N, Vrel D, Rose J, Sanles M, Orsière T, Uboldi C, Grisolia C, Rousseau B, Malard V. Assessment of respiratory toxicity of ITER-like tungsten metal nanoparticles using an in vitro 3D human airway epithelium model. Toxicol Lett, 2015; 238(2): S179. doi:10.1016/j.toxlet.2015.08.519.

Uboldi C, Barth S, Unger RE, Kirkpatrick CJ. Surface modification influences the in vitro toxicity of gold nanoparticles in human alveolar type-II cell lines. ALTEX, 2008; 25 Suppl.1.

Engelhardt B, Uboldi C, Vestweber D, Döring A. Selectins and their ligands are not required for immune cell recruitment across the blood-brain barrier during experimental autoimmune encephalomyelitis. Swiss Medical Weekly, 2007; 137: 20S.

Hermanns MI, Dubruel P, Uboldi C, Schacht E and Kirkpatrick CJ. In vitro toxicity of polyethyleneimine nanoparticles on human distal lung cells in mono- and co-culture. ALTEX, 2007 ; 3/07: 199.

Uboldi C, Alt C, Estess P, Siegelman M, Engelhardt B. L-selectin-deficient mice develop experimental autoimmune encephalomyelitis. Swiss Medical Weekly, Supplément Mars 2006. Société Suisse d’Allergologie et d’Immunologie (SSAI).

Uboldi C, Siegelman M, Engelhardt B. L-selectin-deficient mice develop experimental autoimmune encephalomyelitis. Swiss Medical Weekly, Supplément Mars 2005. Société Suisse d’Allergologie et d’Immunologie (SSAI).

Book chapter

Migliore L, Di Bucchianico S and Uboldi C. The In Vitro Micronucleus Assay and FISH Analysis. 2014; Chapitre 5 de “Genotoxicity and DNA Repair. A practical approach”, série “Methods in Pharmacology and Toxicology”. Editors: L. María Sierra et Isabel Gaivão. Springer New York Publisher. ISSN: 1557-2153.

Doctorate and MSc

2006 Doctoral thesis : “SJL/L-selectin-deficient mice develop experimental autoimmune encephalomyelitis”
2002 MSc : “Tossicologia in vitro di metalli in tracce: studi con colture cellulari”