Mrs Krieguer Blanche , PhD student at UMR IMBE, Chemometrics, Design of Experiments and Expert Systems teamwill publicly defend his thesis work on Friday 7 March 2025 at 9 a.m. in the thesis room on the St Jérôme campus.
In front of a jury made up of :
Summary of work:
Single-use plastic systems are designed for the biopharmaceutical industry to store, transport or mix biopharmaceutical solutions. These systems, made from polymers, are currently sterilised by gamma radiation. The current health context is leading to an increase in the production of products for the pharmaceutical industry. Concerns are emerging about the capacity for gamma radiation sterilisation in the years ahead. Electron beam and X-ray irradiation are being compared for use as alternative methods to gamma sterilisation.
The aim of this thesis is to examine the potential impact of gamma ray, X-ray and electron beam irradiation on two types of film (PE/EVOH/PE and EVA/EVOH/EVA) and on materials formulated from polypropylene, polyethylene and polyamide.
The irradiated samples were analysed using a multi-scale approach: at the molecular, macro-molecular and material levels. The results show that, whatever the polymer, the three irradiation technologies produce equivalent effects: the same types of radicals are generated, and there is no change in the structure and composition of the polymers observed under the analysis conditions. The variations observed between the different classes of polymers are mainly due to the composition of the materials.
IMBE – UMR CNRS 7263 / IRD 237 / Aix Marseille Université / Avignon Université.
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